Reference

Removers for oil films

Removers for oil films. (Sotoyama, Masao; Koto, Masamoto, Japan). Jpn. Kokai Tokkyo Koho JP 58145798 A2 30 Aug 1983 Showa, 2 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C11D010-02. APPLICATION: JP 82-29180 24 Feb 1982. DOCUMENT TYPE: Patent CA Section: 46 (Surface Active Agents and Detergents) Section cross-reference(s): 57 Cleaning agents for glass contain glycerol [56-81-5] or ethylene glycol (I) [107-21-1] 0.2-0.6, gluconic acid [526-95-4] or Na gluconate (II) [527-07-1] 0.2-0.5, Na alkylbenzenesulfonate or a similar surfactant 0.1-0.3, cyclodextrin (III) [12619-70-4] or copper chlorophyllin Na [11006-34-1] <0.08%, and optionally ion blocking agents and a moldproofing agent. Thus, an aq. cleaning agent for an automobile front glass contains glycerol 0.1, I 0.2, II 0.3, phytic acid 0.05, 25% dihydroxydiphenylmethane thiocyanide 0.002, III 0.05, and Na alkylbenzenesulfonate 0.2%.

Protection by chlorophyllin against the covalent binding of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to rat liver DNA

Protection by chlorophyllin against the covalent binding of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to rat liver DNA. Dashwood, Roderick H. (Dep. Environ. Biochem., Univ. Hawaii, Honolulu, HI 96822, USA). Carcinogenesis (London), 13(1), 113-18 (English) 1992. CODEN: CRNGDP. ISSN: 0143-3334. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Chlorophyllin (CHL), a sodium/copper salt of chlorophyll used in the treatment of geriatric patients, exhibits potent antimutagenic activity in a range of assays in vitro and in vivo. The protective effects of CHL were studied in Sprague-Dawley rats using inhibition of carcinogen-DNA binding as an end-point. Animals were administered CHL (150 mg/kg body wt) and [2-14C]2-amino-3-methylimidazo[4,5-f]quinoline (IQ, 50 mg/kg body wt.) by single oral gavage. Covalent IQ-DNA binding in liver was detd. 8, 24 and 48 h after dosing; CHL inhibited binding at these times by 58, 56 and 46% resp., compared with rats given IQ alone. 76180-96-6 and 11006-34-1 are also in the experiment. The total liver burden of IQ-derived radioactivity was reduced in CHL-treated rats, as was the total amt. of radiolabel eliminated in the urine and bile. However, elimination via the feces was increased in rats given CHL, both in terms of total radiolabel eliminated and amt. of unmetabolized IQ in dichloromethane exts. of feces. Finally, pretreatment with CHL in the drinking water, or injection of CHL into isolated loops of intestine in situ, reduced the absorption of IQ from the gut. Collectively, these findings indicate that, when administered simultaneously with the carcinogen, CHL attenuates IQ-DNA binding in rat liver by interacting with IQ in the gut and reducing carcinogen uptake, distribution and metab. The results suggest that further studies should be conducted with respect to the protective mechanisms and possible anti-carcinogenic properties of CHL. .