Reference

The binding of bile acids by hydrotalcite and other antacid preparations

The binding of bile acids by hydrotalcite and other antacid preparations. Llewellyn, A. F.; Tomkin, G. H.; Murphy, G. M. (Res. Dev. Div., Roussel Lab. Ltd., Swindon/Wiltshire, Engl.). Pharm. Acta Helv., 52(1-2), 1-5 (English) 1977. CODEN: PAHEAA. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The bile acid binding properties of hydrotalcite [12304-65-3] have been compared with those of 4 antacids and cholestyramine [11041-12-6]. Hydrotalcite was more effective than the other antacids in removing bile acids from soln. but less effective than cholestyramine. No increase in either fat or bile acid excretion was found on administration of hydrotalcite to 5 healthy volunteers. It is suggested that hydrotalcite therapy may be of particular value in those conditions in which duodenal-gastric reflux of bile acids has been implicated.

Biliary excretion studies with digoxin in man

Biliary excretion studies with digoxin in man. Klotz, U.; Antonin, K. H. (Dr. Margarete Fischer-Bosch-Inst. Klin. Pharmakol., Stuttgart, Ger.). Int. J. Clin. Pharmacol. Biopharm., 15(7), 332-4 (English) 1977. CODEN: IJCBDX. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The 24-h biliary excretion of digoxin (I) [20830-75-5] by patients receiving a single i.v. injection of 0.6 mg or on a maintenance therapy with 0.4 mg/day amounted to only 2-10% of the administered dose. The pattern of the decrease in blood plasma levels of infused I with time was not affected by administration of cholestyramine [11041-12-6], an effective intraluminal binding agent for drugs. The biliary excretion of only minor amts. of I would lead to an insignificant enterohepatic cycling, in agreement with the short-acting nature of I in man.