Detail of "11055-06-4"

CAS Number:
11055-06-4
Name:
2(1H)-Pyridinone,3-[(2R,6S)-3,6-dihydro-5-methyl-6-[(1E,3S,5R)-1,3,5-trimethyl-1-hepten-1-yl]-2H-pyran-2-yl]-4-hydroxy-1-methyl-5-[(1a,2a,3a,4a,5a)-2,3,4,5-tetrahydroxycyclopentyl]-
Molecular Structure:
Formula:
C27H41 N O7
Molecular Weight:
395.69
Synonyms:
2(1H)-Pyridinone,3-[(2R,6S)-3,6-dihydro-5-methyl-6-[(1E,3S,5R)-1,3,5-trimethyl-1-heptenyl]-2H-pyran-2-yl]-4-hydroxy-1-methyl-5-[(1a,2a,3a,4a,5a)-2,3,4,5-tetrahydroxycyclopentyl]- (9CI);2(1H)-Pyridinone, 3-[3,6-dihydro-5-methyl-6-(1,3,5-trimethyl-1-heptenyl)-2H-pyran-2-yl]-4-hydroxy-1-methyl-5-(2,3,4,5-tetrahydroxycyclopentyl)-,stereoisomer; Funiculosine (8CI); Funiculosin; Funiculosin (antibiotic)
Density:
1.278g/cm³
Boiling Point:
623°Cat760mmHg
Flash Point:
330.6°C
Safety:
Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NO_x. Details

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Funiculosin, a new antibiotic: Funiculosin, a new antibiotic. II. Structure elucidation and antifungal activity. Ando, Kunio; Matsuura, Ikutoshi; Nawata, Yoshiharu; Endo, Hisao; Sasaki, Hiroshi; Okytomi, Tsuneo; Saehi, Tetsuji; Tamura, Gakuzo (Res. Lab., Chugai Pharm. Co., Ltd., Toshima, Japan). J. Antibiot., 31(6), 533-8 (English) 1978. CODEN: JANTAJ. ISSN: 0021-8820. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Section cross-reference(s): 1, 33 Funiculosin [11055-06-4] has the structure I, derived from spectral data. The abs. configuration was detd. from x-ray diffraction of its tetrahydro derivs. I inhibited fungal growth for 3 days at concns. comparable to those of polyene macrolide antibiotics. I is highly toxic to rats and mice, but nontoxic to guinea pigs and rabbits.

Funiculosin: an antibiotic with antimycin-like inhibitory properties: Funiculosin: an antibiotic with antimycin-like inhibitory properties. Nelson, B. Dean; Walter, P.; Ernster, L. (Dep. Biochem., Univ. Stockholm, Stockholm, Swed.). Biochim. Biophys. Acta, 460(1), 157-62 (English) 1977. CODEN: BBACAQ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The antibiotic funiculosin (I) [11055-06-4] mimiced the action of antimycin in several ways. It inhibited the oxidn. of NADH and succinate, but not TMPD + ascorbate. The titer for max. inhibition in Mg2+-ATP particles (0.4-0.6 nmol/mg protein) was close to the concns. of cytochromes b and cc1. I also induced the oxidn. of cytochrome cc1 and an extra redn. of cytochrome b [9035-37-4] in the aerobic steady state, and it inhibited duroquinol-cytochrome c reductase [61701-17-5] activity in isolated Complex III. The location of the I binding site was clearly similar to that of antimycin. In addn., I, like antimycin, prevented electron transport from duroquinol to cytochrome b in isolated Complex III if the complex was pre-reduced with ascorbate. I and antimycin differ, however, in the manner in which they modulate the redn. of cytochrome b by ascorbate + TMPD.