Detail of "110590-64-2"

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Development of biomedical materials carrying immobilized functional peptides and discovery of an angiogenic peptide

Development of biomedical materials carrying immobilized functional peptides and discovery of an angiogenic peptide. Nokihara, Kiyoshi; Hamada, Yoshinosuke; Takahashi, Junzo; Okazaki, Masayuki; Matsuura, Nariaki (Shimadzu Scientific Research Inc., Kyoto 604-8442, Japan). Peptide Science, Volume Date 2001, 38th, 359-362 (English) 2002 Japanese Peptide Society. CODEN: PSCIFQ. ISSN: 1344-7661. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 34 Generally, successful tissue regeneration requires both cell adhesion and angiogenesis as well as cell proliferation and differentiation. Biomaterials consisting of peptides designed to satisfy specific structure-activity relationships may generate particularly useful materials for healthcare in the new millennium. For clin.Several substances with their cas registry numbers 110590-64-2 and 292851-89-9 may be metioned in this study. applications this concept has been further extended by the use of allergen-free carrier protein and different designed peptides, whose functions were directed towards cell adhesion and angiogenesis. The present paper describes preliminary studies of the adhesion properties of oligopeptides related to both laminin and osteopontin. The peptides were conjugated with an allergen-free carrier protein. As well as adhesion activity, a significant angiogenic activity was found in a free heptapeptide, SVVYGLR, derived from osteopontin. This peptide was designated AGP (Angiogenic Peptide). An Ala-scan indicated that the middle residues of AGP are important for angiogenic activity.There are some reagents like 110590-64-2 is used in this study. ..

Inhibitive effect of YIGSR on expression of vascular endothelial growth factor and matrix metalloproteinase-3 in osteosarcoma

All Rights Reserved. Inhibitive effect of YIGSR on expression of vascular endothelial growth factor and matrix metalloproteinase-3 in osteosarcoma. Song, Dengxin; Chen, Anmin; Guo, Fengjin; Lei, Ming; Wang, Jiang ( Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Peop. Rep. China). Huazhong Yixue Zazhi, 29(1), 43-45 (Chinese) 2005 Huazhong Yixue Zazhi Bianjibu. CODEN: HYZUAO. ISSN: 1007-5534. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 The possible mechanism of the suppression of invasion and metastasis by YIGSR in osteosarcoma are explored. In the cultured human osteosarcoma MG-63 cell line, different concns. of YIGSR were added. The expression of VEGF and matrix metalloproteinase-3 (MMP-3) in human osteosarcoma was qual. and semi-quant. detected by immunohistochem. and RT-PCR resp. Different concns. of YIGSR could result different expression levels of VEGF and MMP-3 mRNA and proteins in human osteosarcoma. Higher dose of YIGSR could cause the lower expression levels of VEGF and MMP-3 mRNA and proteins in dose-dependent manner with the difference being significant (P<0.05).In this experiment, several chemicals are used like 127464-60-2 and 110590-64-2 The YIGSR can suppress effectively the expression of VEGF and MMP-3 in osteosarcoma cells. YIGSR might play some roles in inhibiting the invasion and metastasis of osteosarcoma. .