Reference

Solid-liquid equilibrium

Solid-liquid equilibrium. Heptanedioic acid-ethyl octadecanoate system. Berchiesi, G.; Vitali, G. (Dip. Sci. Chim., Univ. Camerino, Camerino I-62032, Italy). Int. DATA Ser., Sel. Data Mixtures, Ser. A, (3), 217 (English) 1984. CODEN: ISDMAT. ISSN: 0147-1503. DOCUMENT TYPE: Journal CA Section: 68 (Phase Equilibriums, Chemical Equilibriums, and Solutions) A data table.

Studies on the biosynthesis of biotin by microorganisms

Studies on the biosynthesis of biotin by microorganisms. Part XV. The mode of action of 5-(2-thienyl)valeric acid on biotin biosynthesis. Izumi, Yoshikazu; Fukuda, Hiroko; Tani, Yoshiki; Ogata, Koichi (Dep. Agric. Chem., Kyoto Univ., Kyoto, Japan). Agric. Biol. Chem., 42(3), 579-84 (English) 1978. CODEN: ABCHA6. ISSN: 0002-1369. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) 5-(2-Thienyl)valeric acid (I) [21010-06-0] inhibited the growth of Bacillus sphaericus. The inhibition was restored by th intermediates of biotin [58-85-5] biosynthesis, dethiobiotin (DTB) [533-48-2] and 7,8-diaminopelargonic acid (DAPA) [21738-21-6], as well as biotin. However, the intermediates in earlier steps, 7-keto-8-aminopelargonic acid (KAPA) [4707-58-8] and pimelic acid [111-16-0], had no recovering effect. When Rhodotorula glutinis, which was also sensitive to I, was cultivated in a medium contg. I, the amt. of DTB and biotin in culture filtrate was decreased, whereas that of KAPA was increased. I inhibited DAPA aminotransferase [37259-71-5] activity, which is responsible for DAPA synthesis form KAPA but no other enzyme reactions involved in DTB synthesis from pimelic acid were inhbitited by I. I also inhibited biotin synthesis from DTB. Five other thienyl exhibited no action as biotin antagonists. I inhibited the growth of various microorganisms including bacteria yeasts, molds, and actinomycetes at a concn. of 100 or 500 mg/mL.