Reference

Effect of feeding enramycin on the elimination of Salmonella typhimurium by experimentally infected broiler chickens

Effect of feeding enramycin on the elimination of Salmonella typhimurium by experimentally infected broiler chickens. Yamazaki, Toshiyuki; Morishima, Katsumi; Matsubara, Yukio; Suenaga, Itaru (Anim. Health Prod. Div., Takeda Chem. Ind. Ltd., Osaka 532, Japan). Takeda Kenkyushoho, 43(1/2), 45-52 (English) 1984. CODEN: TAKHAA. ISSN: 0371-5167. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Enramycin [11115-82-5], added to feed at 10 g/ton, was not effective in eliminating S. typhimurium from chickens.

Mode of action of the protein, SP127, which enhances the activity of macrolide antibiotics against Pseudomonas aeruginosa

Mode of action of the protein, SP127, which enhances the activity of macrolide antibiotics against Pseudomonas aeruginosa. Kikuchi, Masakazu; Nakao, Yoshio (Cent. Res. Div., Takeda Chem. Ind., Ltd., Osaka, Japan).There are some reagents with their cas registry numbers 16846-24-5 and 11115-82-5 are used in this study. J. Antibiot., 30(3), 215-20 (English) 1977. CODEN: JANTAJ. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Protein SP127, isolated from the culture broth of Bacillus brevis, enhanced the activities of basic and neutral macrolide antibiotics against P. aeruginosa, but showed no synergistic effect with .beta.-lactam, peptide, aminoglycosidic, polyene, or tetracycline antibiotics. The effect of SP127 was seen with P. aeruginosa and several strains of Escherichia coli, but not with Proteus vulgaris and Staphylococcus aureus, indicating that SP127 showed specificity for both antibiotics and target organisms. The action of the protein may be due, at least in part, to an enhancement of antibiotic penetration into cells of P. aeruginosa. .