Reference

Direct spectrophotometric determination of metformin hydrochloride in pure form and in drug formulations

Direct spectrophotometric determination of metformin hydrochloride in pure form and in drug formulations. Ashour, S.; Kabbani, R. (Department of Chemistry, Faculty of Sciences, Aleppo University, Aleppo, Syria). Analytical Letters, 36(2), 361-370 (English) 2003 Marcel Dekker, Inc. CODEN: ANALBP. ISSN: 0003-2719. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) A simple, sensitive and accurate spectrophotometric method for the detn. of metformin hydrochloride (MfCl) [1115-70-4] is described. The method is based on the formation of charge transfer complex (C.T.) with iodine in acetonitrile medium. Beer's law is obeyed within the concn. range 1.656-72.86 mg/mL of MfCl whereas the optimum concn. range as evaluated by Ringbom's method is 6.62-66.2 mg/mL. The formation const. of the formed complex is evaluated and was found to be 3.8 ′ 104 L mol-1. The molar absorptivity, Sandell sensitivity, relative std. deviation and recovery percent are evaluated. The results are treated statistically. Applying the F- and t-tests and found highly accurate, precise and reproducible. The method is used to det. MfCl in pure form and pharmaceutical prepns. There is no interference from the excipients.

Anti-cellulitis composition

Anti-cellulitis composition. Dabis, Georges (Fr. ). Fr. Demande FR 2320735 11 Mar 1977,9 pp. (French). (France). CODEN: FRXXBL. CLASS: IC: A61K031-155. APPLICATION: FR 75-25069 12 Aug 1975. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Compns. for the transcutaneous treatment of cellulitis comprise at least 1 of the hydrochloride or pamoate salts of metformin, phenformin, butformin, and chlorguanide in combination with an acceptable excipient. For example, a compn. was prepd. contg. TEFOS 1500 10, stearic acid 1, liquid petrolatum 8, galactomannan gel 30, metformin-HCl [1115-70-4] 5.33, and deionized water 45.67 g. Twice daily administration of the above compn. for 30 days caused a marked and rapid treatment of a previously incurable cellulitis in a female patient.