CAS No.1118-89-4,Diethyl L-glutamate hydrochloride Suppliers

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Basic Information

Molecular Structure:
CAS No.:	1118-89-4
Name:	Diethyl L-glutamate hydrochloride
Article Data:	11

Formula:	C₉H₁₇NO₄^.HCl
Molecular Weight:	239.699
Synonyms:	Glutamicacid, diethyl ester, hydrochloride, L- (7CI,8CI);L-Glutamic acid, diethylester, hydrochloride (9CI);Diethylglutamate hydrochloride;Glutamic acid diethyl ester hydrochloride;NSC 12960;NSC 17007;Diethyl L-glutamate hydrochloride;
EINECS:	214-270-4
Density:	1.08g/cm3
Melting Point:	108-110 °C
Boiling Point:	262 °C at 760 mmHg
Flash Point:	86.3 °C
Solubility:	Soluble in water
Appearance:	white crystalline powder
Safety:	24/25
PSA:	78.62000
LogP:	1.72240

Synthetic route

: 56-86-0
L-glutamic acid

: 75-36-5
acetyl chloride

: 1118-89-4
diethyl-L-glutamate hydrochloride

Conditions

Conditions	Yield
In ethanol at 0℃; for 4h; Reflux;	99%

: 64-17-5
ethanol

: 56-86-0
L-glutamic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

Conditions

Conditions	Yield
With thionyl chloride	98%
Stage #1: ethanol; L-glutamic acid With bis(trichloromethyl) carbonate at 70 - 75℃; for 5h; Stage #2: With hydrogenchloride at 20 - 25℃; for 0.5h;	98%
Stage #1: ethanol With thionyl chloride at -10 - 10℃; for 1h; Stage #2: L-glutamic acid at 20 - 80℃; for 2h;	77.76%

: 56-86-0
L-glutamic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

Conditions

Conditions	Yield
at 190 - 195℃; unter vermindertem Druck, Kochen der gebildeten (S)-5-Oxo-pyrrolidin-carbonsaeure-(2) mit aethanol.HCl;

: 64-17-5
ethanol

: 1119-33-1
(S)-2-Amino-pentanedioic acid 5-ethyl ester

: 1118-89-4
diethyl-L-glutamate hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 20℃; for 25h; Cooling with ice;

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 2,5-difluoro-4-nitrobenzoyl chloride

: 7498-31-9
diethyl N-(2,5-difluoro-4-nitrobenzoyl)-L-glutamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 1h;	100%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: (4-Chlorocarbonyl-3,5-difluoro-phenyl)-prop-2-ynyl-carbamic acid tert-butyl ester

: 141412-75-1
diethyl N-(4-(N-(tert-butyloxycarbonyl)-N-prop-2-ynylamino)-2,6-difluorobenzoyl)-L-glutamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 2h;	100%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 4-(2-amino-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)-benzoic acid

: 150585-92-5
diethyl N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamate

Conditions

Conditions	Yield
With diethyl cyanophosphonate; triethylamine In N,N-dimethyl-formamide at 20℃; for 18h;	100%

: 38239-45-1
5-bromo-3-methyl-thiophene-2-carboxylic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 160743-92-0
2(S)-{[(5-bromo-3-methylthiophene-2-yl)carbonyl]amino}pentanedioic acid diethyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 18h;	99%

: 5781-53-3
monomethyl oxalyl chloride

: 1118-89-4
diethyl-L-glutamate hydrochloride

: (S)-2-(methoxyoxalyl-amino)pentanedioic acid diethyl ester

Conditions

Conditions	Yield
In toluene	99%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 404586-94-3
1-(tert-butoxy)-2-(tert-butoxy)carbonyl-1,2-dihydroisoquinoline

: 130696-54-7
diethyl (tert-butoxycarbonyl)-L-glutamate

Conditions

Conditions	Yield
In diethyl ether Heating;	98%

Raw Materials

64-17-5

56-86-0

Downstream Products

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Specification

L-Glutamic acid diethyl ester hydrochloride, with the CAS register number 1118-89-4, could also be known to us as diethylester, hydrochloride,l-glutamicaci; diethyll-glutaminatehydrochloride; l-glutamic acid alpha,gamma-diester hydrochloride; l-glutamic acid alpha, gamma-diethyl ester hydrochloride; glutamic acid(oet)-oet hcl; h-glu(oet)-oet hcl ,etc. It is a white crystalline powder and if you need the safety information, you could refer to the WGK Germany 3 to get some. As for its usage, it is uaually used in the organic synthesis and pharmaceutical intermediates. The product categories of this chemical are as below: glutamic acid [glu, e], amino acids and derivatives, amino acid ethyl esters, biochemistry, amino hydrochloride, glutamic acidneurotransmitters, excitatory amino acids, neurotransmitters, peptide synthesis.

Physical properties about L-Glutamic acid diethyl ester hydrochloride are: (1)#H bond acceptors: 5; (2)#H bond donors: 2; (3)#Freely Rotating Bonds: 9; (4)Polar Surface Area: 55.84; (5)Index of Refraction: 1.452; (6)Molar Refractivity: 50.78 cm³; (7)Molar Volume: 188.1 cm³; (8)Polarizability: 20.13 ×10-24cm³; (9)Surface Tension: 37.6 dyne/cm; (10)Density: 1.08 g/cm³; (11)Flash Point: 86.3 °C; (12)Enthalpy of Vaporization: 49.97 kJ/mol; (13)Boiling Point: 262 °C at 760 mmHg; (14)Vapour Pressure: 0.0112 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)InChI=1S/C9H17NO4.ClH/c1-3-13-8(11)6-5-7(10)9(12)14-4-2;/h7H,3-6,10H2,1-2H3;1H/t7-;/m0./s1;
(2)InChIKey=WSEQLMQNPBNMSL-FJXQXJEOSA-N;
(3)SmilesO(C(=O)[C@H](CCC(OCC)=O)N)CC.Cl

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	> 2gm/kg (2000mg/kg)		Pharmaceutical Chemistry Journal Vol. 25, Pg. 246, 1991.