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CAS No.: | 111841-85-1 |
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Name: | abecarnil |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C24H24 N2 O4 |
Molecular Weight: | 404.466 |
Synonyms: | 6-(Benzyloxy)-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylicacid 1-methylethyl ester; Abecarnil; Isopropyl 6-(benzyloxy)-4-(methoxymethyl)-b-carboline-3-carboxylate; ZK112119 |
Density: | 1.246g/cm3 |
Melting Point: | 150-151° |
Boiling Point: | 620.2°Cat760mmHg |
Flash Point: | 328.9°C |
Hazard Symbols: | Human systemic effects. |
Safety: | Human systemic effects. When heated to decomposition it emits toxic vapors of NOx. |
PSA: | 73.44000 |
LogP: | 5.00670 |
abecarnil
Conditions | Yield |
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With hydrogenchloride In isopropyl alcohol at 70℃; for 24h; | 94% |
abecarnil
Conditions | Yield |
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With trichloroisocyanuric acid; triethylamine for 16h; Ambient temperature; Yield given; |
isopropyl 4-methoxy-2-butynoate
abecarnil
Conditions | Yield |
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Multi-step reaction with 2 steps 1: 57 percent / Pd(OAc)2; PPh3; n-Bu3N / dimethylformamide / 100 °C 2: 94 percent / aq. HCl / propan-2-ol / 24 h / 70 °C View Scheme |
abecarnil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 57 percent / Pd(OAc)2; PPh3; n-Bu3N / dimethylformamide / 100 °C 2: 94 percent / aq. HCl / propan-2-ol / 24 h / 70 °C View Scheme |
abecarnil
6-benzyloxy-4-methoxymethyl-β-carboline-3-carbaldehyde
Conditions | Yield |
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With sodium hydroxide; chloro-trimethyl-silane; triethylamine In ethanol; toluene |
abecarnil
Conditions | Yield |
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Multi-step reaction with 2 steps 1: sodium hydroxide; chloro-trimethyl-silane; triethylamine / ethanol; toluene 2: potassium hydroxide; hydroxylamine hydrochloride / (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; N,N-dimethyl-formamide View Scheme |
abecarnil
6-Benzyloxy-3-(3-isoxazolyl)-4-methoxymethyl-β-carboline
Conditions | Yield |
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Multi-step reaction with 3 steps 1: sodium hydroxide; chloro-trimethyl-silane; triethylamine / ethanol; toluene 2: potassium hydroxide; hydroxylamine hydrochloride / (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; N,N-dimethyl-formamide 3: sodium hydroxide; N-Bromosuccinimide; triethylamine / N,N-dimethyl-formamide View Scheme |
abecarnil
6-benzyloxy-3-(5-ethoxy-3-isoxazolyl)-4-methoxymethyl-β-carboline
Conditions | Yield |
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Multi-step reaction with 3 steps 1: sodium hydroxide; chloro-trimethyl-silane; triethylamine / ethanol; toluene 2: potassium hydroxide; hydroxylamine hydrochloride / (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; N,N-dimethyl-formamide 3: N-Bromosuccinimide; triethylamine / N,N-dimethyl-formamide View Scheme |
1. | orl-man TDLo:571 µg/kg:BAH | BCPHBM British Journal of Clinical Pharmacology. 35 (1993),386. |