Detail of "111900-33-5"

CAS Number:
111900-33-5
Name:
1,3-Cyclopentanedicarboxylicacid, 1-amino-, (1R,3R)-
Molecular Structure:
Formula:
C7H11 N O4
Molecular Weight:
173.17
Synonyms:
1,3-Cyclopentanedicarboxylicacid, 1-amino-, (1R-trans)-; (1R,3R)-1-Amino-1,3-cyclopentanedicarboxylic acid

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Inhibition of cyclic AMP formation by a selective metabotropic glutamate receptor agonist: Inhibition of cyclic AMP formation by a selective metabotropic glutamate receptor agonist. Schoepp, Darryle D.; Johnson, Bryan G.; Monn, James A. (Lilly Res. Lab., Eli Lilly and Co.Some commonly used reagents like 111900-33-5 and 39026-63-6 are used in this experiment., Indianapolis, IN 46256, USA). J. Neurochem., 58(3), 1184-6 (English) 1992. CODEN: JONRA9. ISSN: 0022-3042. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) In this study , the selective metabotropic excitatory ammino acid (EAA) agonist trans-(±)-1-aminocyclopentane-1,3-dicarboxylic acid (I) and its isomers were examd. for effects on basal and forskolin-stimulated cAMP formation in slices of the rat hippocampus. I had little effect on basal cAMP but inhibited forskolin-stimulated cAMP formation in a biphasic manner. The 1S,3R isomer produced potent but only partial (~50%) inhibition of forskolin-stimulated cAMP formation. The 1R,3S isomer fully inhibited forskolin-stimulated cAMP but with lower potency that the 1S,3R isomer. These results show that in addn. to the formation of phosphoinositide-derived second messengers, the cellular consequences of selectively activating hippocampal metabotropic EAA receptors include an alteration of cellular cAMP levels. .