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| CAS No.: | 1124-11-4 |
|---|---|
| Name: | Tetramethylpyrazine |
| Article Data: | 58 |
| Molecular Structure: | |
|
|
|
| Formula: | C8H12N2 |
| Molecular Weight: | 136.197 |
| Synonyms: | BS factor;Chuanxingzine;Pyrazine,tetramethyl- (6CI,7CI,8CI,9CI);Ligustrazine;NSC 36080;NSC 46451;Tetramethylpyrazine;Tetrapyrazine;Ligustrazin; |
| EINECS: | 214-391-2 |
| Density: | 1.08 g/cm3 |
| Melting Point: | 82-86 °C |
| Boiling Point: | 192.7 °C at 760 mmHg |
| Flash Point: | 71.6 °C |
| Solubility: | Soluble in water (4 g/L at 20°C). |
| Appearance: | white crystals or powder |
| Hazard Symbols: |
 Xn, Xi
|
| Risk Codes: | 22-37/38-41-36/37/38 |
| Safety: | 26-39-24/25-37/39-36 |
| PSA: | 25.78000 |
| LogP: | 1.71020 |
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- 1124-11-4
Tetramethylpyrazine
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water | 96% |
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; hexane for 4h; Heating; | 90% |
- 52648-79-0
3-amino-butan-2-one
- 1124-11-4
Tetramethylpyrazine
| Conditions | Yield |
|---|---|
| Stage #1: 3-amino-butan-2-one With acetic acid for 1.3h; Stage #2: With potassium bromate; sodium hydrogensulfite Time; | 87.2% |
| Conditions | Yield |
|---|---|
| With carbonylchlorohydrido(4,5-bis((diisopropylphosphino)methyl)acridine)ruthenium(II); ammonia In toluene at 150℃; under 5250.53 Torr; for 36h; Inert atmosphere; Glovebox; | 85% |
| With aluminium oxide catalysts; ammonia at 400℃; |
- 135636-66-7
butane-2,3-dione mono-oxime
- 1124-11-4
Tetramethylpyrazine
| Conditions | Yield |
|---|---|
| With palladium on activated charcoal; ammonium formate In water at 80 - 90℃; for 4h; Solvent; Temperature; | 84.6% |
| With hydrogenchloride; tin Behandlung des entstandenen Methyl-<α-amino-aethyl>-ketons mit Alkalien; | |
| With hydrogenchloride; tin(ll) chloride Behandlung des entstandenen Methyl-<α-amino-aethyl>-ketons mit Alkalien; |
- 1124-11-4
Tetramethylpyrazine
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water | 76.1% |
- 21419-24-9
3-Amino-2-butanone hydrochloride
- 1124-11-4
Tetramethylpyrazine
| Conditions | Yield |
|---|---|
| With air; sodium acetate In methanol at 60℃; | 73% |
- 1124-11-4
Tetramethylpyrazine
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water pH=3 - ~ 8; | 61.1% |
| Conditions | Yield |
|---|---|
| In water | 55.5% |
| Conditions | Yield |
|---|---|
| With hydrogenchloride; pyridoxal 5'-phosphate; (S)-1,2,3,4-tetrahydronapht-1-yl-amine; amine transaminase-113 In water; dimethyl sulfoxide at 30℃; for 72h; pH=7.4; Reagent/catalyst; Enzymatic reaction; chemoselective reaction; | 50% |
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Chemistry
IUPAC Name:2,3,5,6-tetramethylpyrazine
Molecular Formula:C8H12N2
Molecular Weight:136.194280 g/mol
Appearance:White crystals
Melting Point:77-80 °C(lit.)
Boiling Point:190 °C(lit.)
Flash Point:128-130°C/200mm
density:1.08
FEMA:3237
BRN:113100
Synonyms of TETRAMETHYLPYRAZINE(1124-11-4):
BS Factor;Ligustrazine;Pyrazine,tetramethyl-;Tetramethylpyrazin;tetramethyl-pyrazin;2,3,5,6-TETRAMETHYLPYRAZINE;2,3,5,6-TETRAMETHYLPYRAZINES;2,3,5,6-TETRAMETHYL-1,4-PYRAZINE
Categories of TETRAMETHYLPYRAZINE(1124-11-4):
Pyrazine;Heterocyclic Compounds;Pyrazines;Mono- & Polyalkylpyrazines;pyrazine Flavor;Alphabetical Listings;Flavors and Fragrances;Q-Z;Certified Natural ProductsFlavors and Fragrances;Building Blocks;Heterocyclic Building Blocks
Uses
TETRAMETHYLPYRAZINE(1124-11-4) is used as a flavoring agent, sweetness enhancer of alcohol, corrective and supplements of cigarettes.
Toxicity Data With Reference
| 1. | orl-rat LD50:1910 mg/kg | DCTODJ Drug and Chemical Toxicology. 3 (1980),249. | ||
| 2. | ipr-mus LD50:800 µg/kg | IJCREE International Journal of Crude Drug Research. 23 (1985),119. | ||
| 3. | ivn-mus LD50:239 mg/kg | CMJODS Chinese Medical Journal (Beijing, English Edition). New Series. (Guozi Shudian, Beijing, People’s Republic of China) V.1- 1975- 4 (1978),319. |
Consensus Reports
Safety Profile
Hazard Codes:Xn,Xi
Risk Statements:22-37/38-41-36/37/38
22:Harmful if swallowed
37/38:Irritating to respiratory system and skin
41:Risk of serious damage to eyes
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-39-24/25-37/39-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
39:Wear eye/face protection
24/25:Avoid contact with skin and eyes
37/39:Wear suitable gloves and eye/face protection
36:Wear suitable protective clothing
WGK Germany:3
RTECS:UQ3905000
HS Code:29339990
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.
Specification
First Aid Measures of TETRAMETHYLPYRAZINE(1124-11-4):
Ingestion:Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin:Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes:Flush eyes with
Storage of TETRAMETHYLPYRAZINE(1124-11-4):
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.