Reference

Preparation of piperidinylmethyloxazolidinone derivatives as blood platelet aggregation inhibitors

Preparation of piperidinylmethyloxazolidinone derivatives as blood platelet aggregation inhibitors. Tsaklakidis, Christos; Schaefer, Wolfgang; Doerge, Liesel; Esswein, Angelika; Friebe, Walter-Gunar (Boehringer Mannheim Gmbh, Germany). Ger. Offen. DE 19524765 A1 9 Jan 1997, 14 pp. (German). (Germany). CODEN: GWXXBX. CLASS: ICM: C07D413-14.Several reagents such as 187084-55-5 is used here. ICS: C07D413-04; A61K031-445; A61K031-495. ICI: C07D413-14, C07D213-26, C07D263-20, C07D211-62; C07D413-14, C07D241-06, C07D263-20, C07D211-62; C07D413-04, C07D213-26, C07D263-20. APPLICATION: DE 1995-19524765 7 Jul 1995. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Title compds. [I; X, Y = CH, N; Z = N, CH, C(OH); A = (CH2)n; B = bond, or when Z = N, then B can also = CO; D = (CHR3)mCO2; n = 0-5; m = 0, 1; R1, R2 = H, alkyl, aryl; R1R2 = atoms to form a 5-6 membered isocyclic ring; R3 = H, OR5, NR6R7; R4 = H, OR5; R5 = H, alkyl, aryl, aralkyl; R6 = H, alkyl, aralkyl; R7 = H, alkyl aralkyl, acyl, alkylsulfonyl, arylsulfonyl], were prepd. as blood platelet aggregation inhibitors (no data). Thus, Et (2S)-1-oxiran-2-ylmethylpiperidine-4-carboxylate (prepn. given) and 3,4,5,6-tetrahydro-2H-[1,4']bipyridin-4-ylamine (prepn. given), were refluxed 48 h in EtOH and the residue was stirred 15 h with carbonyldiimidazole in DMF to give after sapon. 1-[(5S)-2-oxo-3-(3,4,5,6-tetrahydro-2H-[1,4']bipyridin-4-yl)oxazolidin-5-y lmethyl]piperidine-4-carboxylic acid. .