Detail of "112811-71-9"

CAS Number:
112811-71-9
Name:
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester
Molecular Structure:
Formula:
C₁₆H₁₅F₂NO₄
Molecular Weight:
323.29
Synonyms:
Ethyl1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylate;Ethyl1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylate;3-Quinolinecarboxylicacid, 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-, ethyl ester;
Density:
1.415 g/cm³
Melting Point:
179-181 °C
Boiling Point:
459.695 °C at 760 mmHg
Flash Point:
231.816 °C
Appearance:
Pale yellow solid

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(6,7-Substituted-8-alkoxy-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinec arboxylic acid O3,O4)bis(acyloxy-O)borates and the salts thereof, and methods for their manufacture: (6,7-Substituted-8-alkoxy-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinec arboxylic acid O3,O4)bis(acyloxy-O)borates and the salts thereof, and methods for their manufacture. Takagi, Naomi; Fubasami, Hironobu; Matsukubo, Hiroshi (Kyorin Pharmaceutical Co., Ltd., Japan). Eur. Pat. Appl.Chemicals with cas numbers 10043-35-3 and 112811-71-9 also play role. EP 464823 A1 8 Jan 1992, 13 pp. DESIGNATED STATES: R: BE, CH, DE, ES, FR, GB, IT, LI, NL, SE. (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07F005-02. ICA: A61K031-47; C07D215-56. APPLICATION: EP 91-111139 4 Jul 1991. PRIORITY: JP 90-178765 6 Jul 1990. DOCUMENT TYPE: Patent CA Section: 29 (Organometallic and Organometalloidal Compounds) A process for the prepn. of (6,7-substituted 8-alkoxy-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid bis(acyloxy) borate of general formula I comprises the treatment of carboxyl compd. II with triacyloxyborate deriv. BR3. E.g., II (X = Y = F, R1 = Me, R2 = H, R3 = Et) (200 g) was added to a mixt. of boric acid (57.2 g) and zinc chloride (1.24 g) in acetic anhydride (300 mL) and acetic acid (400 mL) at a temp. of 50-60° to give 249 g of I (X = Y = F, R1 = Me, R2 = H, R = acetato). .

Separation of the main impurity demethylgatifloxacin from gatifloxacin and its synthesis and identification: Separation of the main impurity demethylgatifloxacin from gatifloxacin and its synthesis and identification. Wang, Xiuzhen; Wang, Xintu; Wang, Erhua (Medicinal and Chemical Institute, China Pharmaceutical University, Nanjing 210009, Peop. Rep. China). Zhongguo Yaoke Daxue Xuebao, 34(3), 272-273 (Chinese) 2003 Zhongguo Yaoke Daxue. CODEN: ZHYXE9. ISSN: 1000-5048. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) The main impurity of gatifloxacin was identified. Demethylgatifloxacin was synthesized in four steps from Et 2-(3-methoxy-2,4,5-trifluorobenzoyl)-3-(cyclopropylamino)acrylate through cyclization, chelation, N-piperazination, and hydrolysis, and identified by LC/MS, UV, 1HNMR, 13CNMR, MS.Except for chemicals metioned above, 112811-71-9 and 139693-52-0 are also used. .