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Detail of "112984-60-8"

  • CAS Number:
  • 112984-60-8
  • Name:

  • 1H,4H-[1,3]Thiazeto[3,2-a]quinoline-3-carboxylicacid, 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-

  • Superlist Name:
  • Ulifloxacin
  • Molecular Structure:
  • Formula:
  • C16H16FN3O3S
  • Molecular Weight:
  • 349.38
  • Synonyms:
  • AF 3013;NAD 394;NM 394;6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid;
  • Density:
  • 1.58 g/cm3
  • Boiling Point:
  • 577 °C at 760 mmHg
  • Flash Point:
  • 302.8 °C
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CAS No.112984-60-8 Ulifloxacin

Assay:98%  Appearance:Yellow powde...

Supplier:Taiyuan RHF CO., ltd. [ China (Mainland)]

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CAS No.112984-60-8 Ulifloxacin

1H,4H-[1,3]Thiazeto[3,2-a]quinoline-3-carboxylic acid, 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-

Supplier:TCS INDUSTRY LIMITED [ China (Mainland)]

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CAS No.112984-60-8 Ulifloxacin

Assay:98%

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CAS No.112984-60-8 Ulifloxacin

intermediate of Prulifloxacin

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CAS No.112984-60-8 Ulifloxacin

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CAS No.112984-60-8 Ulifloxacin

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CAS No.112984-60-8 Ulifloxacin

Assay:>97.5%  Appearance:off-white po...  Package:According to...  Application:intermediate...

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CAS No.112984-60-8 Ulifloxacin

Assay:97%min  Appearance:Off-white to...  Package:25kg Cardboa...  Application:Prulifloxaci...

Product No: BBTF-001 Product name: Ulifloxacin Chemical name: 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid Molecular formula: C16H16FN3O3S Molecular weight : 349.38 Specification: Water: 9-12% Remarks: Regular Commercial prod

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CAS No.112984-60-8 Ulifloxacin

6-fluoro-1-methyl-4-oxo- 7-(1-piperazinyl)-4H-(1,3) S,N-containing heterocyclic bi- (3,2-a) quinoline-3-carboxylic acid

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CAS No.112984-60-8 Ulifloxacin

CAS No.: 112984-60-8 Molecular formula: C16H16FN3O3S Molecular weight: 349.38 Appearance: pale yellow to off-white crystalline powder Purity: not less than 97.0% Packing: 25kgs/drum, packed with paper carton drums Demanding supply

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CAS No.112984-60-8 Ulifloxacin

Product name:6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylic acid CAS NO.:112984-60-8 Prulifloxacin

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CAS No.112984-60-8 Ulifloxacin

1H,4H-[1,3]Thiazeto[3,2-a]quinoline-3-carboxylic acid, 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-

Supplier:Changzhou EST Chemical Co., Ltd. [ China (Mainland)]

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CAS No.112984-60-8 Ulifloxacin

6-Fluoro-1-Methyl-4-Oxo-7-(1-Piperazinyl)-4H-(1,3)-Thiazeto(3,2-Alpha)Quinoline-3-Carboxylic Acid

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CAS No.112984-60-8 Ulifloxacin

25kg/drum pharma grade assay:99%

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CAS No.112984-60-8 Ulifloxacin

6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-(1,3)-thiazeto(3,2-a)quinoline-3-carboxylic acid

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CAS No.112984-60-8 Ulifloxacin

Spec: >98%

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CAS No.112984-60-8 Ulifloxacin

Appearance light yellow solid Assay 98.0% min

Supplier:Chongqing Ensky Chemcial Co., Ltd [ China (Mainland)]

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CAS No.112984-60-8 Ulifloxacin

Supplier:Shanghai Maigochem Co., Ltd. [ China (Mainland)]

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CAS No.112984-60-8 Ulifloxacin

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CAS No.112984-60-8 Ulifloxacin

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CAS No.112984-60-8 Ulifloxacin

Supplier:Akshaya Laboratories Pvt. Ltd [ India]

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Reference

Pharmacokinetics and tolerability of prulifloxacin after single oral administration
Pharmacokinetics and tolerability of prulifloxacin after single oral administration. Picollo, Rossella; Brion, Nils; Gualano, Virginie; Millerioux, Laurette; Marchetti, Marcello; Rosignoli, Maria Teresa; Dionisio, Paolo (Medical Departmenta and Analytical Development, A.C.R.A.E S.p.A, Rome 00040, Italy). Arzneimittel-Forschung, 53(3), 201-205 (English) 2003 Editio Cantor Verlag. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The pharmacokinetic properties and tolerability of three different strengths of prulifloxacin (CAS 123447-62-1), a new antibacterial agent prodrug of AF3013 (CAS 112984-60-8), have been investigated in a randomized, cross-over study performed in 12 Caucasian male subjects (age range 19-34 yr). Prulifloxacin was administered as a single oral dose at the dosages of 300, 450 and 600 mg. Plasma concns. of the active metabolite AF3013 were detd. in blood samples collected before the administration (pre-dose) and at 15, 30, 45 min, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 16, 24, 36 and 48 h after dosing. Urine samples were also collected. Detn. in biol. samples was performed using validated and specific HPLC methods. The following parameters were calcd.: Cmax, tmax, AUC0-tm AUC0-￥, t1/2, V/F, Aeur, CLren and fe. The anal. of variance performed on dose-normalized data after logarithmic transformation evidenced no statistically significant differences between the three doses concerning Cmax and AUC. Friedman's test applied to tmax and t1/2 did not show any statistically significant difference between doses. A significant linear relation between doses and AUC0-￥ was detected (p < 0.05). Very high urinary concns. and the relatively long terminal half-life (10-12 h) suggest that a once-daily application would show adequate clin. efficacy, esp. in urinary infections. The safety profile of the three doses was very good.
Additional comment (1)
Additional comment (1). In vitro anti-Mycobacterium avium complex activities of new quinolones in focus [1]. Tsuyuguchi, Kazunari (Chest Disease Research Inst., Kyoto Univ., Japan).In this article, certain chemicals are used. Some of their cas registry numbers are 112984-60-8 and 161967-81-3 Kekkaku, 71(9), 536-537 (Japanese) 1996 Nippon Kekkakubyo Gakkai. CODEN: KEKKAG. ISSN: 0022-9776. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 10 The antibacterial actions of the new quinolones T 3761, CS 940, AM 1155, OPC 17116, NM 394, ciprofloxacin, ofloxacin, levofloxacin, and sparfloxacin against Mycobacterium avium complex were compared with other antibiotics in vitro. .
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