Detail of "113-45-1"

Reference

Evidence for presynaptic antagonism by amantadine of indirectly acting central stimulants

Evidence for presynaptic antagonism by amantadine of indirectly acting central stimulants. Menon, M. K.; Vivonia, Charlotte A.; Haddox, Victor G. (Psychopharmacol. Res. Lab., Veterans Adm. Med. Cent., Sepulveda, CA 91343, USA). Psychopharmacology (Berlin), 82(1-2), 89-92 (English) 1984. CODEN: PSCHDL. ISSN: 0033-3158. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In mice, amantadine [768-94-5] pretreatment (150 mg/kg, but not 10 mg/kg, 2 h prior to testing) markedly inhibited the locomotor stimulation produced by submaximal doses of d-amphetamine [51-64-9], amfonelic acid [15180-02-6], methylphenidate [113-45-1], caffeine [58-08-2], memantine [19982-08-2], phencyclidine [77-10-1], and cocaine [50-36-2]. A 50-mg/kg dose was ineffective in blocking the effects of caffeine and memantin, but blocked the responses to the other 5 stimulants. Amantadine did not modify the locomotor stimulant effect of apomorphine [58-00-4] in reserpinized mice. These results indicate that amantadine acts as a presynaptic antagonist to the above 7 stimulants. 768-94-5 and 50-36-2 which are cas registry numbers of chemicals are mentioned. Even the highest dose of amantadine did not modify the hyperactivity induced in mice by morphine [57-27-2] and levorphanol [77-07-6]. This result is consistent with evidence, showing opiate actions at postsynaptic striatal neurons, sites where presumably amantadine is unable to exert an antagonist effect. Amantadine did not modify the central depressant effects of ethyl alc. [64-17-5] and pentobarbital [76-74-4]. Amantadine could be of value as a pharmacol. tool in understanding the mode of action of central stimulants, and in the management of stimulant abuse. The present data do not support the currently held view that the antiparkinsonism effect of amantadine results from its ability to potentiate the central effects of dopamine [51-61-6]. .

Cholinergic modulation of stimulant-induced behavior

Cholinergic modulation of stimulant-induced behavior. Gonzalez, Larry P.; Ellinwood, Everett H., Jr.Chemicals with cas numbers 300-62-9 and 58-00-4 also play role. (Dep. Physiol. Biophys., Univ. Illinois, Chicago, IL 60680, USA). Pharmacol., Biochem. Behav., 20(3), 397-403 (English) 1984. CODEN: PBBHAU. ISSN: 0091-3057. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 1 The effects of the cholinesterase inhibitor physostigmine [57-47-6] and several other cholinergic and anticholinergic drugs, on stimulant-induced behavior were examd. Stereotypy was inhibited by physostigmine to the same degree whether induced by direct (apomorphine [58-00-4]) or by indirect acting (amphetamine [300-62-9] and methylphenidate [113-45-1]) stimulants. Apparently, the site of cholinergic modulation of stimulant-induced stereotypy is postsynaptic to the dopaminergic neurons which mediate stereotypy. .