CAS No.113-52-0,Imipramine hydrochloride Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	113-52-0
Name:	Imipramine hydrochloride
Article Data:	1

Formula:	C₁₉H₂₅ClN₂
Molecular Weight:	316.874
Synonyms:	N-(g-Dimethylaminopropyl)iminodibenzyl hydrochloride;Praminil;Presamine;Promiben;SK-Pramine;Surplix;Tipramine;Tofranil;Tofranile;5H-Dibenz[b,f]azepine,5-[3-(dimethylamino)propyl]-10,11-dihydro-, monohydrochloride (8CI);Eupramin;Feinalmin;Imavate;Imidol;Imilanyle;Imipramine monohydrochloride;Imiprin;Imizinum;Iramil;Chrytemin;Censtim;Censtin;Apo-Imipramine;5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride;Dyna-Zina;N-(3-Dimethylaminopropyl)iminodibenzylhydrochloride;Melipramine hydrochloride;
EINECS:	204-030-7
Density:	1.041g/cm3
Melting Point:	168-170 °C
Boiling Point:	403.1 °C at 760 mmHg
Flash Point:	179.7 °C
Solubility:	Soluble in water
Appearance:	UN 1230 3/PG 2
Hazard Symbols:	Xn
Risk Codes:	23/25-36/38-36/37/38-22
Safety:	7-16-24-33-45-36-26
Transport Information:	White solid
PSA:	6.48000
LogP:	4.74200

Synthetic route

Reaxys ID: 19040915: Reaxys ID: 19040915

: 113-52-0
Imipramine hydrochloride

Conditions

Conditions	Yield
Stage #1: In acetone for 0.5h; Heating / reflux; Stage #2: In di-isopropyl ether at 0 - 5℃;

: 113-52-0
Imipramine hydrochloride

: 7732-18-5
water

: potassium hexacyanoferrate(III)

: imipraminium ferricyanide monohydrate

Conditions

Conditions	Yield
In water E-2 M solns. were mixed; ppt. was filtered, thoroughly washed with distd. water, dried at room temp., elem. anal.;	99.5%

...Expand

: sodium hexanitro cobaltate(III)

: 113-52-0
Imipramine hydrochloride

: 7732-18-5
water

: imipraminium cobaltnitrite monohydrate

Conditions

Conditions	Yield
In water E-2 M solns. were mixed; ppt. was filtered, thoroughly washed with distd. water, dried at room temp., elem. anal.;	99.5%

...Expand

: 113-52-0
Imipramine hydrochloride

: 54-21-7
sodium salicylate

: 1085510-17-3
imipramine salicylate

Conditions

Conditions	Yield
In water at 20 - 62℃; for 19.95h;	95.1%
In water at 20 - 62℃; for 19.95h;	95.1%

: 113-52-0
Imipramine hydrochloride

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 6487-79-2
2-Formylimipramine

Conditions

Conditions	Yield
With trichlorophosphate at 100℃; for 4h; Formylation; Vilsmeier Reaction;	59%

: 113-52-0
Imipramine hydrochloride

: 122-51-0
orthoformic acid triethyl ester

: 129961-34-8
[3-(2-{Bis-[5-(3-dimethylamino-propyl)-10,11-dihydro-5H-dibenzo[b,f]azepin-2-yl]-methyl}-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-dimethyl-amine

Conditions

Conditions	Yield
With tetrafluoroboric acid diethyl ether In diethyl ether; dichloromethane for 6h; Ambient temperature;	8%

: 113-52-0
Imipramine hydrochloride

A: 50-47-5
desipramine

B: 494-19-9
9,10-dihydrodibenzazepine

C: 796-28-1
10-Hydroxyimipramine

Conditions

Conditions	Yield
In water Ambient temperature; M. griseo-cyanus (ATCC 1207a); further microbial agents;	A 10 mg B n/a C n/a

...Expand

: 113-52-0
Imipramine hydrochloride

A: 50-47-5
desipramine

B: 494-19-9
9,10-dihydrodibenzazepine

C: 796-28-1
10-Hydroxyimipramine

D: 303-70-8
2-hydroxyimipramine

Conditions

Conditions	Yield
In water for 480h; Ambient temperature; C. blakesleeana (ATCC 8688a); further microbial agents; Further byproducts given;	A n/a B n/a C 30 mg D 88 mg

...Expand

: 113-52-0
Imipramine hydrochloride

A: 494-19-9
9,10-dihydrodibenzazepine

B: 796-28-1
10-Hydroxyimipramine

C: 303-70-8
2-hydroxyimipramine

D: 6829-98-7
imipramine N-oxide

Conditions

Conditions	Yield
In water; N,N-dimethyl-formamide for 480h; Ambient temperature; C. blakesleeana (ATCC 8688a); further microbial agents; Further byproducts given;	A n/a B 30 mg C 88 mg D n/a

...Expand

: 113-52-0
Imipramine hydrochloride

A: 494-19-9
9,10-dihydrodibenzazepine

B: 6829-98-7
imipramine N-oxide

Conditions

Conditions	Yield
In water; N,N-dimethyl-formamide for 360h; Ambient temperature; F. oxysporum f. sp. cepae (ATCC 11711); further microbial agents;	A 7 mg B n/a
In water for 312h; Ambient temperature; A. flavipes (ATCC 16795); further microbial agents;	A n/a B 112 mg

Downstream Products

303-70-8

50-47-5

494-19-9

6829-98-7

10075-24-8

796-28-1

Total:100 Page 1 of 3 1 2 3 Next>>

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Toxicity Data With Reference

1.		dni-oin-unr 10 g/L	JCLBA3 Journal of Cell Biology. 47 (1970),182a.
2.		cyt-oin-unr 10 g/L	JCLBA3 Journal of Cell Biology. 47 (1970),182a.
3.		orl-man TDLo:2143 µg/kg/2D-I	JCLPDE Journal of Clinical Psychiatry. 44 (1983),225.
4.		orl-chd TDLo:25 mg/kg:CNS,PUL	JAMAAP JAMA, Journal of the American Medical Association. 179 (1962),456.
5.		orl-chd LDLo:15 mg/kg	BMJOAE British Medical Journal. 1 (1974),261.
6.		orl-chd TDLo:27 mg/kg:CNS,KID	JAMAAP JAMA, Journal of the American Medical Association. 230 (1974),1405.
7.		orl-wmn TDLo:107 mg/kg:CNS,CVS	NEJMAG New England Journal of Medicine. 268 (1963),33.
8.		orl-wmn TDLo:30 mg/kg:PNS,CNS	BMJOAE British Medical Journal. 2 (1959),1458.
9.		orl-rat LD50:305 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 18 (1971),185.
10.		ipr-rat LD50:72 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 21 (1971),391.
11.	&nb

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Human poison by ingestion. An experimental poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. An experimental teratogen. Human systemic effects by ingestion: sleep, somnolence, convulsions, muscle contraction or spasticity, coma, blood pressure decrease, dyspnea (difficulty in breathing), paresthesia (abnormal sensations), and kidney changes. Experimental reproductive effects. Mutation data reported. Used in the treatment of depression. When heated to decomposition it emits very toxic fumes of NO_x and HCl. See also DIAZEPAM.