Detail of "113-53-1"

Reference

Effect of antidepressants on the absorption of serotonin by human thrombocytes

Effect of antidepressants on the absorption of serotonin by human thrombocytes. Oksenkrug, G.In this study， 5118-29-6 and 14368-24-2 are also used. F. (Leningr. Nauchno-Issled. Psikhonevrol. Inst. im. Bekhtereva, Leningrad, USSR). Farmakol. Toksikol. (Moscow), 40(2), 146-8 (Russian) 1977. CODEN: FATOAO. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) All 15 antidepressants tested decreased the absorption of serotonin [50-67-9] by human thrombocytes in vitro. In decreasing order of effectiveness they were: chlorimipramine [303-49-1], imipramine [50-49-7], prothiaden [113-53-1], quipazine [4774-24-7], amitriptyline [50-48-6], trausabun [5118-29-6], imipramine N-oxide [6829-98-7], nortriptyline [72-69-5], demethylimipramine [50-47-5], trimipramine [739-71-9], noveril [315-80-0], ludiomil [10347-81-6], iprindole [5560-72-5], tacitin [10085-81-1], and origen [14368-24-2]. .

Electroanalytical study of tricyclic antidepressants

Electroanalytical study of tricyclic antidepressants. Bishop, E.; Hussein, W. (Chem. Dep., Univ. 50-47-5 and 303-49-1 are also occured in this study. Exeter, Exeter EX4 4QD, UK). Analyst (London), 109(1), 73-80 (English) 1984. CODEN: ANALAO. ISSN: 0003-2654. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) The anodic electroactivity, shown by clomipramine [303-49-1], desipramine [50-47-5], dibenzepin [4498-32-2], dothiepin [113-53-1], imipramine [50-49-7], opipramol [315-72-0] and trimipramine [739-71-9] was studied at rotating disk electrodes of Pt and Au in H2SO4 and in buffer media by a single scan voltammetry, and at stationary disk electrodes by cyclic voltammetry. Potentiostatic and amperostatic coulometry were used to det. the no. of electrons involved in the reactions. Rapid voltammetric detns. of the active drugs were evaluated in the best medium, 0.1 mol/L H2SO4. Adsorption of the oxidn. product on the electrodes prevents detn. of clomipramine and restricts the concn. range for imipramine and trimipramine. The kinetic parameters, half-wave potentials, mass and charge-transfer rate consts., and charge-transfer coeffs. were detd. under a wide range of conditions. Electrode reaction mechanisms were elucidated. Dothiepin is oxidized by a single 4-electron step to the sulfone. The azepines are oxidized to a radical that dimerizes rapidly before a further 1-electron step produces the dimer diradical; opipramol can undergo a further 4-electron oxidn. of the piperazine ring in the side chain to the 1,4-dihydropyrazine deriv. .