Reference

Interaction of some neuroleptic and antidepressive agents with human ceruloplasmin

Interaction of some neuroleptic and antidepressive agents with human ceruloplasmin. Loevstad, Rolf A. (Inst. Med. Biochem., Univ. Oslo, Oslo, Norway). Biochem. Pharmacol., 25(16), 1877-9 (English) 1976. CODEN: BCPCA6. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 7 Of 10 neuroleptics and antidepressive agents studied, only promazine (I) [58-40-2] and prothipendyl (II) [303-69-5] were rapidly oxidized by human ceruloplasmin (III). I activity towards imipramine [50-49-7], desipramine [50-47-5], and opipramol [315-72-0] was considerably lower, whereas chloroprothixene [113-59-7], tiothixene [3313-26-6], amitriptyline [50-48-6], protriptyline [438-60-8], and haloperidol [52-86-8] did not react at all. 50-47-5 and 51-41-2 which are cas registry numbers of substances are two of reagents here. A central ring N atom was apparently essential for III activity, and the folded phenothiazine ring system was favorable for a rapid reaction. I and II activated the conversion of noradrenaline [51-41-2] to noradrenochrome [490-89-1] in the presence of III. .

Effect of antidepressants on the dynamics of electrically induced convulsive seizures in rats

Effect of antidepressants on the dynamics of electrically induced convulsive seizures in rats. Chugunov, V. V. (Nauchno-Issled. Inst. Biol. Ispyt. Khim. Soedin., Kupavna, USSR). Khim.-Farm. Zh., 10(8), 12-16 (Russian) 1976. CODEN: KHFZAN. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Melipramine-HCl (I) [113-52-0] and amitriptyline (II) [50-48-6] at 10 and 33% of resp. 50-47-5 and 50-48-6 which are cas registry numbers of chemicals are mentioned. LD50 values given i.m. to rats completely prevented the tonic phase of electroshock-induced convulsions and prolonged the duration of the initial and clonic phases. Fluoracizine [27312-93-2], insidon [909-39-7], chlorprothixene [113-59-7], sonapax [50-52-2], prenolon [145-13-1] and desipramine [50-47-5] shortened the tonic phase and prolonged initial and clonic phases of convulsions. Iprazide [54-92-2] and nuredal [51-12-7] had only a weak effect on the tonic phase and no effect on the other phases. .