Detail of "113-80-4"

Reference

Central cardiovascular effects of vasotocin, oxytocin and vasopressin in conscious rats

Central cardiovascular effects of vasotocin, oxytocin and vasopressin in conscious rats. Feuerstein, G.; Zerbe, R. L.; Faden, A. I. (Neurobiol. Res. Unit, Unif. Serv. Univ. Health Sci., Bethesda, MD, USA). J. Pharmacol. Exp. Ther., 228(2), 348-53 (English) 1984. CODEN: JPETAB. ISSN: 0022-3565. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) 8-Arginine-vasotocin (AVT) [113-80-4], oxytocin [50-56-6], and 8-arginine-vasopressin (AVP) [113-79-1] were injected intracerebroventricularly (i.c.v.) and(or) into the hypothalamus of awake, freely moving rats to investigate the potential role of these neuropeptides in central cardiovascular control. AVT (0.015-10 nmol) injected i.c.v. caused dose-dependent pressor responses; low doses also elicited tachycardia, whereas the higher doses (1 and 10 nmol) produced bradycardia. In contrast, oxytocin injections into the lateral ventricle (0.015-100 nmol) had no cardiovascular effects. Plasma vasopressin was not affected by administration of oxytocin or AVT except at the highest dose of AVT. AVT (0.1 or 1 nmol) and AVP (0.015 or 0. 113-79-1 and 50-56-6 which are cas registry numbers of substances are two of reagents here.1 nmol) injected into the hypothalamic nucleus preopticus medialis (POM) increased blood pressure and heart rate; these changes were much greater than with comparable doses of AVT injected i.c.v. Plasma levels of norepinephrine [51-43-4] and epinephrine [51-41-2], but not vasopressin, were elevated during the pressor period induced by 1 nmol of AVT injected into the POM. The pressor and cardiac accelerating effects of AVT (1 nmol) injected into the POM were diminished in bilaterally adrenal demedullated, bretylium-treated rats. The data suggest a role for AVT, but not oxytocin, in central cardiovascular control through activation on the sympathoadrenomedullary axis. The anteroventral hypothalamus might play a central role in these autonomic effects of vasotocin. Evidently, AVP and AVT share some central autonomic effects due to structural similarities. .

Correlation between cAMP in isolated frog skin epithelium and stimulation of sodium transport and osmotic water flow by antidiuretic hormone and phosphodiesterase inhibitors

Correlation between cAMP in isolated frog skin epithelium and stimulation of sodium transport and osmotic water flow by antidiuretic hormone and phosphodiesterase inhibitors. Johnsen, A. H.; Nielsen, R. (Inst. Biol. Chem. A, August Krogh Inst., Copenhagen DK-2100, Den.). Gen. Comp. Endocrinol., 54(1), 144-53 (English) 1984. CODEN: GCENA5. ISSN: 0016-6480. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The cAMP [60-92-4] level in isolated frog skin epithelium was stimulated by a range of concns. of 8-arginine vasotocin (AVT) [113-80-4] and compared to active Na transport measured as short-circuit current (SCC). The response of SCC and osmotic H2O flow (OWF) to AVT was investigated in sep. expts. The SCC was ~3 times more sensitive to AVT than was OWF. Measurable increments of cAMP above the basal level were found only with AVT concns. eliciting greater than the half-maximal response of SCC. Two models are offered to explain the findings: (A) total SCC depends on epithelial cAMP with a sigmoidal relation and (B) epithelial cAMP exists in 2 sep. pools of which only 1 is accessible to AVT, and SCC stimulation depends on cAMP in the AVT-controlled pool in a simple saturable fashion. Correlation between cAMP and SCC after stimulation with theophylline resembled that after AVT. Papaverine [58-74-2] (10 mM) induced only small changes in SCC inspite of a substantial increase in cAMP level. 58-74-2 and 60-92-4 which are cas registry numbers of substances are two of reagents here. Higher concns. of papaverine inhibited both basal and AVT-stimulated SCC, but the cAMP level was further increased. This effect of papaverine may be due to a simultaneous block of another rate-detg. process. Papaverine had no effect on basal or AVT-stimulated OWF despite a marked stimulation of the cAMP level. Thus, the role of cAMP as mediator of the hydroosmotic action of AVT must be questioned. .