Reference

The effect of anionic surfactants on the release of chlorpheniramine from a polymer matrix tablet

The effect of anionic surfactants on the release of chlorpheniramine from a polymer matrix tablet. Daly, P. B.; Davis, S. S.; Kennerley, J. W. (Dep. Pharm., Univ. Nottingham, Nottingham NG7 2RD, UK). Int. J. Pharm., 18(1-2), 201-5 (English) 1984. CODEN: IJPHDE. ISSN: 0378-5173. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Tablets contg. 9004-65-3 and 151-21-3 which are cas registry numbers of substances are two of reagents here. 15% Na lauryl sulfate [151-21-3] gave a zero order in vitro release profile of chlorpheniramine maleate [113-92-8] from hydroxypropyl Me cellulose [9004-65-3] tablets with a considerable retardation of release rate which was dependent on the concn. of the surfactant. Nonionic and cationic surfactants had no effect on the release rate. .

Pathogenesis of gastric ulceration produced by acetazolamide in rats

Pathogenesis of gastric ulceration produced by acetazolamide in rats. Cho, C. H.; Chen, S. M.; Chen, S. W.; Chow, C. K.; Lai, K. H.; Pfeiffer, C. J. (Dep. Med. Res., Veterans Gen. Hosp., Taipei 112, Taiwan). Digestion, 29(1), 5-11 (English) 1984. CODEN: DIGEBW. ISSN: 0012-2823. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Relative high doses of acetazolamide [59-66-5] (100 and 200 mg/kg, s.c.) induced severe gastric hemorrhagic ulceration in rats. This ulceration was aggravated by oral administration of HCl, but was inhibited by NaHCO3. Further, the severity of ulceration was also decreased by pretreatment with methysergide [361-37-5], chlorpheniramine [113-92-8], or cimetidine [51481-61-9]. These protective effects were affirmed by an increase in serotonin [50-67-9] and histamine [51-45-6] released from the stomach after acetazolamide treatment. Acetazolamide injection also increased the protein level, but reduced the sialic acid content, in the gastric secretion, indicating that the gastric mucosal barrier may have been damaged. The prostaglandin E2 [363-24-6] content of the gastric mucosa was not affected by the drug; however, carbonic anhydrase [9001-03-0] activity was markedly reduced in a dose-dependent manner. Thus, it is suggested that the ulceration induced by acetazolamide is mainly due to the inhibition of carbonic anhydrase activity and mucus secretion. The increases in serotonin and histamine released may also have been contributing factors for gastric ulcer formation.Except for chemicals metioned above, 51481-61-9 and 51-45-6 are also used. .