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113274-56-9

Basic Information
CAS No.: 113274-56-9
Name: HIRUDIN (54-65) (DESULFATED)
Molecular Structure:
Molecular Structure of 113274-56-9 (HIRUDIN (54-65) (DESULFATED))
Formula: C66H93N13O25
Molecular Weight: 1468.52
Synonyms: GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR-LEU-GLN;HIRUDIN FRAGMENT 54-65 NON-SULFATED;H-GLY-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR-LEU-GLN-OH;Hirudin;
Density: 1.384±0.06 g/cm3(Predicted)
Boiling Point: 1913.6±65.0 °C(Predicted)
PSA: 624.45000
LogP: 1.59880
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    Introduction Hirudin Source Leech and its salivary glands Composition 65-66 amino acids composed of small molecules Category Thrombin Natural Specific Inhibitor Application Medicine CAS number 113274-5

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    113274-56-9 - Physico-chemical Properties Molecular Formula C66H93N13O25 Molar Mass 1468.52 Density 1.384±0.06 g/cm3(Predicted) Boling Point 1913.6±65.0 °C(Predicted) pKa

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Specification

The Hirudin (54-65) (desulfated) is an organic compound with the formula C66H93N13O25. It belongs to the product categories of Hirudin Fragments; Miscellaneous Peptides; Peptides for Cell Biology. Its CAS registry number is 113274-56-9. Hirudin is a naturally occurring peptide in the salivary glands of medicinal leeches (such as Hirudo medicinalis) that has a blood anticoagulant property.

Hirudin is a naturally occurring peptide in the salivary glands of medicinal leeches (such as Hirudo medicinalis) that has a blood anticoagulant property. Natural hirudin contains a mixture of various isoforms of the protein. However, recombinant techniques can be used to produce homogeneous preparations of hirudin. It is difficult to extract large amounts of hirudin from natural sources, so a method for producing and purifying this protein using recombinant biotechnology has been developed. This has led to the development and marketing of a number of hirudin based anticoagulant pharmaceutical products such as Lepirudin (Refludan) , Hirudin derived from Hansenula (Thrombexx, Extrauma) and Desirudin (Revasc/Iprivask). Several other direct thrombin inhibitors are derived chemically from hirudin.