Reference

Fluorenylalkylimidazole derivatives

Fluorenylalkylimidazole derivatives. Robertson, David Wayne (Lilly, Eli, and Co. , USA). Eur. Pat. Appl. EP 138415 A2 24 Apr 1985, 48 pp. DESIGNATED STATES: R: BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07D233-60. ICS: C07D405-06; A61K031-415. APPLICATION: EP 84-306431 20 Sep 1984. PRIORITY: US 83-534469 21 Sep 1983. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 63 Imidazoles I [R,R1 = H, Me, halogen; R2, R3 = H, Me; R4 = H, alkyl; R5 = (un)substituted XH; R4R5 = XCH2CR9R10(CH2)mX; R6,R7R8 = H, Me, Et; R9,R10 = H, Me; X = O, S; n = 0-2; m = 0,1] were prepd. Thus, bromination of 2-acetylfluorene with CuBr2 gave bromide II (R11 = Br), which reacted with imidazole in DMF to give 55% II (R11 = 1-imidazolyl). Redn. of this compd. with NaBH4 gave the alc. 1133-80-8 is just another one chemical used in this study. III. III showed an ED50 of 22 mg/kg orally for inhibition of electroshock-induced convulsions in mice. .