CAS No.1135-24-6,Ferulic Acid Suppliers

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Basic Information

Molecular Structure:
CAS No.:	1135-24-6
Name:	Ferulic Acid
Article Data:	223

Formula:	C₁₀H₁₀O₄
Molecular Weight:	194.187
Synonyms:	2-propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-;(E)-3-(4-hydroxy-3-methoxy-phenyl)prop-2-enoate;3-(4-hydroxy-3-methoxy-phenyl)prop-2-enoic acid;3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid;caffeic acid 3-methyl ether;3-(4-Hydroxy-3-methoxyphenyl)acrylic acid;2-Propenoic acid,3-(4-hydroxy-3-methoxyphenyl)-;2-Propenoic acid, 3- (4-hydroxy-3-methoxyphenyl)-;Ferulate;3-Methoxy-4-hydroxy-trans-cinnamate;Cinnamic acid, 4-hydroxy-3-methoxy-;3-methoxy-4-hydroxycinnamic acid;Natural ferulic acid;Ferulic acid 99.5%;FerulicAcid;Gamma-Oryzanol, Ferulic acid;Fumalic acid;
EINECS:	214-490-0
Density:	1.316 g/cm³
Melting Point:	168-172 °C(lit.)
Boiling Point:	372.3 °C at 760 mmHg
Flash Point:	150.5 °C
Solubility:	Soluble in water
Appearance:	Pale Yellow Solid
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36-37/39
PSA:	66.76000
LogP:	1.49860

Synthetic route

: 4046-02-0
ethyl 4-hydroxy-3-methoxycinnamate

: 1135-24-6
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

Conditions

Conditions	Yield
With sodium hydroxide In methanol; water for 3h; Reflux;	100%
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 8h;	98%
With Sporotrichum thermophile type C feruloyl esterase; water Enzyme kinetics;
With recombinant Tan410 In aq. phosphate buffer at 35℃; for 0.75h; pH=7; Enzymatic reaction;

: 141-82-2
malonic acid

: 121-33-5
vanillin

: 1135-24-6
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

Conditions

Conditions	Yield
With piperidine; pyridine for 0.0833333h; microwave irradiation;	94%
With piperidine; p-toluidine In toluene at 80℃; for 3h; Knoevenagel Condensation;	94%
With bismuth(III) chloride for 0.0833333h; Doebner condensation; Microwave irradiation; Neat (no solvent);	93%

: (E)-methoxymethyl 3-[3-methoxy-4-(methoxymethoxy)phenyl]acrylate

: 1135-24-6
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

Conditions

Conditions	Yield
bismuth(lll) trifluoromethanesulfonate In tetrahydrofuran; water at 20℃; for 0.416667h;	90%

: 2309-07-1
Methyl ferulate

: 1135-24-6
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

Conditions

Conditions	Yield
With lithium hydroxide monohydrate In tetrahydrofuran; methanol; water at 20℃; for 18h; Inert atmosphere; Schlenk technique; Glovebox;	89%
With Sporotrichum thermophile type C feruloyl esterase; water Enzyme kinetics;

: 141-82-2
malonic acid

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 1135-24-6
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

Conditions

Conditions	Yield
With 1-n-butyl-3-methylimidazolim bromide at 60℃; for 8h; Knoevenagel-Doebner condensation;	83%

: 98885-93-9, 115851-80-4, 147556-16-9
curcumin

A: 1135-24-6
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

B: 121-33-5
vanillin

C: (1E,4Z,8Z,11E)-5,8-Dihydroxy-1,12-bis-(4-hydroxy-3-methoxy-phenyl)-6,7-bis-[1-(4-hydroxy-3-methoxy-phenyl)-meth-(E)-ylidene]-dodeca-1,4,8,11-tetraene-3,10-dione

Conditions

Conditions	Yield
With 5,10,15,20-tetra(2',6'-dichlorophenyl)porphyrinatoiron(III) chloride; dihydrogen peroxide; acetylacetone In dichloromethane at 20℃; for 2.5h;	A 2.1% B 3.3% C 70%

...Expand

: C10H9IO3

: 1135-24-6
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

Conditions

Conditions	Yield
With copper(I) oxide; 1-D-O-Methyl-chiro-inositol; sodium hydroxide In water at 120℃; for 6h;	60%

: 85364-70-1
3-methyl-4-nitro-5-<2-(3-methoxy-4-hydroxyphenyl)ethenyl>isoxazole

: 1135-24-6
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

Conditions

Conditions	Yield
With sodium hydroxide for 2h; Heating;	49.7%

: 331-39-5
caffeic acid

: S-(5’-adenosyl)-L-methionine chloride

: 1135-24-6
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

Conditions

Conditions	Yield
O-methyltransferase pH 7;

: 63644-62-2, 123821-69-2, 62706-35-8
(E,E)-3-(4-hydroxy-3-methoxyphenyl)allyl 3-(4-hydroxy-3-methoxyphenyl)acrylate

A: 1135-24-6
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

B: 458-35-5, 32811-40-8, 69056-21-9
coniferal alcohol

C: 63644-71-3
(E)-4-(3-methoxy-1-propenyl)-2-methoxyphenol

Conditions

Conditions	Yield
Product distribution; hydrolysis by various reaction conditions to various product;

...Expand

Raw Materials

331-39-5

141-82-2

Downstream Products

64-19-7

93-35-6

3943-74-6

4482-31-9

2305-13-7

751-38-2

59-02-9

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Chemistry

IUPAC Name: (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Empirical Formula: C₁₀H₁₀O₄
Molecular Weight: 194.184g/mol
EINECS: 208-679-7
Structure of 4-Hydroxy-3-methoxycinnamic acid (CAS NO.1135-24-6):

Index of Refraction: 1.626
Molar Refractivity: 52.26 cm³
Molar Volume: 147.4 cm³
Polarizability: 20.72×10^-24cm³
Surface Tension: 56.1 dyne/cm
Density: 1.316 g/cm³
Flash Point: 150.5 °C
Enthalpy of Vaporization: 65.35 kJ/mol
Melting Point: 168-172 °C(lit.)
Boiling Point: 372.3 °C at 760 mmHg
Vapour Pressure: 3.34E-06 mmHg at 25°C
Water Solubility: soluble
Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Cinnamic Acids, Esters and Derivatives;Aromatics
Canonical SMILES: COC1=C(C=CC(=C1)C=CC(=O)O)O
Isomeric SMILES: COC1=C(C=CC(=C1)/C=C/C(=O)O)O
InChI: InChI=1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+
InChIKey: KSEBMYQBYZTDHS-HWKANZROSA-N

Uses

1.It is an antioxidant in the sense that it is reactive toward free radicals such as reactive oxygen species (ROS). ROS and free radicals are implicated in DNA damage, cancer, accelerated cell aging.
2.It may have pro-apoptotic effects in cancer cells, thereby leading to their destruction.
3.It may be effective at preventing cancer induced by exposure to the carcinogenic compounds benzopyreneand 4-nitroquinoline 1-oxide.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD	intraperitoneal	> 350mg/kg (350mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA BEHAVIORAL: REGIDITY	Indian Journal of Pharmaceutical Sciences. Vol. 49, Pg. 77, 1987.
mouse	LD50	intravenous	857mg/kg (857mg/kg)		Chemical and Pharmaceutical Bulletin. Vol. 38, Pg. 1620, 1990.

Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 3
RTECS: UD3365500
Hazard Note: Irritant
Hazardous Substances Data: 1135-24-6(Hazardous Substances Data)

Specification

4-Hydroxy-3-methoxycinnamic acid , its cas register number is 1135-24-6. It also can be called 3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid ; 3-Methoxy-4-hydroxycinnamic acid ; 4-Hydroxy-3-methoxy cinnamic acid ; CCRIS 3256 ; Cinnamic acid, 4-hydroxy-3-methoxy- ; Coniferic acid ; Ferulic acid .
4-Hydroxy-3-methoxycinnamic acid (CAS NO.1135-24-6) is a pale yellow solid.