CAS No.113507-06-5,Moxidectin Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	113507-06-5
Name:	Moxidectin
Article Data:	4

Formula:	C₃₇H₅₃NO₈
Molecular Weight:	639.83
Synonyms:	MilbemycinB, 5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino)-,[6R,23E,25S(E)]-;Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-(methoxyimino)-,(6R,23E,25S)- (9CI);23-Methoxime-LL-F 28249a;CL 301423;ProHeart 6;Quest;Quest (parasiticide);Vetdectin Oral Drench;Milbemycin B,5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-buten-1-yl)-6,28-epoxy-23-(methoxyimino)-,(6R,23E,25S)-;
EINECS:	635-129-7
Density:	1.23 g/cm³
Melting Point:	132 °C
Boiling Point:	790 ºC at 760 mmHg
Flash Point:	431.6 ºC
Appearance:	Appearance White or pale yellow, amorphous powder
Hazard Symbols:	T,N
Risk Codes:	25-50
Safety:	45-61-24/25
PSA:	116.04000
LogP:	5.72890

Synthetic route

: 112124-81-9
23-oxynemadectin

: 113507-06-5
moxidectin

Conditions

Conditions	Yield
With N-methoxylamine hydrochloride; sodium acetate In methanol at -10 - 0℃; for 8h;	88.6%

: 593-56-6
N-methoxylamine hydrochloride

: 112124-81-9
23-oxynemadectin

: 113507-06-5
moxidectin

Conditions

Conditions	Yield
With sodium acetate In methanol; water for 1h; Ambient temperature;	80%
With sodium acetate In methanol at -15℃; for 0.5h;
Stage #1: N-methoxylamine hydrochloride; 23-oxynemadectin With sodium acetate; acetic acid In 1,4-dioxane at 20℃; for 10h; Inert atmosphere; Stage #2: With toluene-4-sulfonic acid In methanol at 0℃; for 4h; Temperature; Reagent/catalyst;	0.015 mol

: 113462-09-2
C38H52O9

: 113507-06-5
moxidectin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: de-esterification 2: 80 percent / NaOAc / methanol; H2O / 1 h / Ambient temperature View Scheme

: 108702-57-4
C38H54O9

: 113507-06-5
moxidectin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: pyridinium dichromate / or Swern oxidation 2: de-esterification 3: 80 percent / NaOAc / methanol; H2O / 1 h / Ambient temperature View Scheme

: nemadectin

: 113507-06-5
moxidectin

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 4-methyl-morpholine; triethylamine / dichloromethane / 20 - 25 °C 2: O-phenyl phosphorodichloridate; triethylamine; Isopropyl acetate / dichloromethane; dimethyl sulfoxide / -25 - 35 °C 3: sodium acetate / dichloromethane; methanol / -13 °C 4: sodium hydroxide; methanol / dichloromethane / -13 °C View Scheme
Multi-step reaction with 4 steps 1: 4-methyl-morpholine; triethylamine / dichloromethane / 20 - 25 °C 2: O-phenyl phosphorodichloridate; triethylamine; Isopropyl acetate / dichloromethane; dimethyl sulfoxide / -25 - 35 °C 3: sodium hydroxide; methanol / dichloromethane / -13 °C / Inert atmosphere 4: sodium acetate / methanol / 0.5 h / -15 °C View Scheme

: 5-(4-chlorophenoxyacetyl)oxynemadectin

: 113507-06-5
moxidectin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: O-phenyl phosphorodichloridate; triethylamine; Isopropyl acetate / dichloromethane; dimethyl sulfoxide / -25 - 35 °C 2: sodium acetate / dichloromethane; methanol / -13 °C 3: sodium hydroxide; methanol / dichloromethane / -13 °C View Scheme
Multi-step reaction with 3 steps 1: O-phenyl phosphorodichloridate; triethylamine; Isopropyl acetate / dichloromethane; dimethyl sulfoxide / -25 - 35 °C 2: sodium hydroxide; methanol / dichloromethane / -13 °C / Inert atmosphere 3: sodium acetate / methanol / 0.5 h / -15 °C View Scheme

: 113507-06-5
moxidectin

: 119718-45-5
moxidectin

Conditions

Conditions	Yield
With 2-Mercaptobenzothiazole In toluene Heating;

Raw Materials

593-56-6

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Chemistry

Molecular Structure of Moxidectin (CAS NO.113507-06-5):

Systematic Name: (2aE,4E,4'Z,5'S,6R,6'S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(1E)-1,3-Dimethylbut-1-en-1-yl]-20,20b-dihydroxy-4'-(methoxyimino)-5',6,8,19-tetramethyl-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b-tetrad ecahydro-2H,17H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-17-one
Molecular Weight: 639.81862 [g/mol]
Molecular Formula: C₃₇H₅₃NO₈
XLogP3-AA: 4.3
H-Bond Donor: 2
H-Bond Acceptor: 9
Index of Refraction: 1.581
Molar Refractivity: 172.46 cm³
Molar Volume: 517.1 cm³
Surface Tension: 41.3 dyne/cm
Density: 1.23 g/cm³
Flash Point: 431.6 °C
Enthalpy of Vaporization: 130.93 kJ/mol
Boiling Point: 790 °C at 760 mmHg
Vapour Pressure: 7.61E-29 mmHg at 25 °C
storage temp.: 2-8 °C
Classification Code: Anthelmintics; Antinematodal Agents; Antiparasitic [veterinary]; Insecticides
Product Categories: Anthelmintic, antiparasitic.; METI - MZAntibiotics; MLSAnalytical Standards; Antibiotics; BacteriostaticAntibiotics; beta-Lactam StructureAlphabetic; Chemical Structure; Chromatography; M; Pharmacology Standards; Principle

Uses

Moxidectin (CAS NO.113507-06-5) is a parasiticide used for the prevention and control of heartworm and intestinal worms, and can be found in treatments prescribed for animals such as dogs, cats, horses, cattle and sheep. It is also used for the prevention of red mite in caged birds. Application methods for moxidectin vary by treatment, and include oral, topical, and injectable solutions.

Safety Profile

Safety Information of Moxidectin (CAS NO.113507-06-5):
RIDADR: 2588
HazardClass: 6.1(b)
PackingGroup: III

Specification

Moxidectin (CAS NO.113507-06-5), its Synonyms are (6R,25S)-5-O-Demethyl-28-deoxy-25-((E)-1,3-dimethyl-1-butenyl)-6,28-epoxy-23-oxomilbemycin B 23-(E)-(O-methyloxime) ; CL 301,423 ; Cydectin ; Milbemycin B, 5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S(E))- ; (2aE,4E,5'R,6R,6'S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-6'-((E)-1,3-Dimethyl-1-butenyl)-5',6,6',7,10,11,14,15,17a,20,20a,20b-dodecahydro-20,20b-dihydroxy-5',6,8,19-tetramethylspiro(11,15-methano-2H,13H,17H-furo(4,3,2-pq)(2,6)benzodioxacyclooctadecin-13,2'-(2H)pyran)-4',17(3'H)-dione 4'-(E)-(O-methyloxime) .

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