CAS No.114-86-3,Phenformin Suppliers

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Basic Information

Molecular Structure:
CAS No.:	114-86-3
Name:	Phenformin
Article Data:	10

Formula:	C₁₀H₁₅N₅
Molecular Weight:	205.263
Synonyms:	Biguanide,1-phenethyl- (6CI,8CI);(Phenylethyl)biguanide;1-Phenethylbiguanide;Cronoformin;Debeone;Diabis;Dibiraf;Dibotin;Fenfoduron;Fenformin;Fenormin;Glukopostin;Glyphen;Phenethylbiguanide;
EINECS:	204-057-4
Density:	1.24 g/cm³
Melting Point:	280-282°C
Boiling Point:	413.7 °C at 760 mmHg
Flash Point:	204 °C
Appearance:	white powder
Hazard Symbols:	Xn
Risk Codes:	22
Safety:	36
PSA:	97.78000
LogP:	2.72010

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Chemistry

Molecular Structure of Phenformin (CAS NO.114-86-3):

IUPAC Name: 1-(diaminomethylidene)-2-phenethylguanidine
Empirical Formula: C₁₀H₁₅N₅
Molecular Weight: 205.2596
EINECS: 204-057-4
H bond acceptors: 5
H bond donors: 6
Freely Rotating Bonds: 4
Polar Surface Area: 34.44 Å²
Index of Refraction: 1.62
Molar Refractivity: 57.93 cm³
Molar Volume: 164.8 cm³
Surface Tension: 53.8 dyne/cm
Density: 1.24 g/cm³
Flash Point: 204 °C
Enthalpy of Vaporization: 66.65 kJ/mol
Boiling Point: 413.7 °C at 760 mmHg
Vapour Pressure: 4.71E-07 mmHg at 25°C
Classification Code: Drug / Therapeutic Agent; Hypoglycemic agents; Tumor data
InChI
InChI=1/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)
Smiles
c1(CCNC(NC(N)=N)=N)ccccc1

Production

It derived from phenylethylamine hydrochloride and dicyandiamide by heating at 142 °C, responsed by post-processing.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
guinea pig	LD50	subcutaneous	16mg/kg (16mg/kg)	Medicina Experimentalis. Vol. 8, Pg. 237, 1963.
guinea pig	LDLo	intravenous	30mg/kg (30mg/kg)	"Hemoperfusion: Kidney and Liver Support and Detoxification, Proceedings of the International Symposium, Haifa, 1979," Sideman, S., and T.M.S. Chang, eds., Multiple parts, New York, Hemisphere Pub. Corp., 1980-Vol. 1, Pg. 337, 1980.
mouse	LD50	intraperitoneal	140mg/kg (140mg/kg)	Bollettino Chimico Farmaceutico. Vol. 97, Pg. 396, 1958.
mouse	LD50	oral	450mg/kg (450mg/kg)	Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 42, Pg. 236, 1985.
rat	LD50	oral	650mg/kg (650mg/kg)	Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 42, Pg. 236, 1985.

Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NO_x.Safety information of Phenformin (CAS NO.114-86-3):
Hazard Codes: Harmful Xn
Risk Statements: 22
R22:Harmful if swallowed.
Safety Statements: 36
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: DU2200000

Specification

Phenformin , with CAS number of 114-86-3, can be called Phenethvdiguanide ; N′-β-Phenethylformamidin-ylliminourea ; N′-β-Fenetilformamidiniliminourea (italian) ; β-Phenethylbiguanide ; Phenformin Hydrochloride ; Phenformine [INN-French] ; Phenforminum [INN-Latin] ; Fenformina . Phenformin (CAS NO.114-86-3) is hypoglycemic agents, applicable to all types of diabetes. Can be made into a variety of products such as glass cloth laminated board, mold plastic film, adhesives, insulating paint, foam and fiber.