Detail of "1147-76-8"

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Synthesis of new lipophilic phosphonate and phosphonamidate analogs of N-acetylmuramyl-D-isoglutamine related to LK 423

Some chemicals with cas registry numbers like 1147-76-8 are also used.Several reagents such as 1147-76-8 is used here. Synthesis of new lipophilic phosphonate and phosphonamidate analogs of N-acetylmuramyl-D-isoglutamine related to LK 423. Gobec, Stanislav; Urleb, Uros (Faculty of Pharmacy, University of Ljubljana, Ljubljana 1000, Slovenia). Molecules [online computer file], 7(4), 394-404 (English) 2002 Molecular Diversity Preservation International. URL: http://www.mdpi.org/molecules/papers/70400394.pdf. CODEN: MOLEFW. ISSN: 1420-3049. DOCUMENT TYPE: Journal; (online computer file) CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 29 A syntheses of three new muramyl dipeptide (MDP) analogs related to LK 423 as potential immunomodulators are presented. The synthesis of phosphonamidate MDP analogs was carried out by coupling of methyl(1R,S)-1-(N-benzyloxycarbonyl)aminoethyl phosphonate with Me D-isoglutamate hydrochloride, or (2S)-2-hydroxyglutaric acid di-Me ester, followed by coupling with 2-(2-phthalimidoethoxy)acetic acid, or 5-phthalimidopentanoic acid. The dipeptide part of the lead compd. was modified by introducing a phosphonamide isostere instead of the amide bond between L-alanine and D-glutamic acid (or D-isoglutamine), yielding new MDP analogs I (R1 = NH2, R2 = OMe, Y = CH2; R1 = R2 = OCH2Ph, Y = O). Furthermore, the amide bond between L-Ala and D-Glu was replaced by a phosphonate isostere, giving peptidyl phosphonate I (R1 = R2 = OMe, Y = O). The scope and limitations of the synthetic strategies employed are discussed. ..

Synthesis of new lipophilic phosphonate and phosphonamidate analogs of N-acetylmuramyl-D-isoglutamine related to LK 423

Some chemicals with cas registry numbers like 1147-76-8 are also used.Several reagents such as 1147-76-8 is used here. Synthesis of new lipophilic phosphonate and phosphonamidate analogs of N-acetylmuramyl-D-isoglutamine related to LK 423. Gobec, Stanislav; Urleb, Uros (Faculty of Pharmacy, University of Ljubljana, Ljubljana 1000, Slovenia). Molecules [online computer file], 7(4), 394-404 (English) 2002 Molecular Diversity Preservation International. URL: http://www.mdpi.org/molecules/papers/70400394.pdf. CODEN: MOLEFW. ISSN: 1420-3049. DOCUMENT TYPE: Journal; (online computer file) CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 29 A syntheses of three new muramyl dipeptide (MDP) analogs related to LK 423 as potential immunomodulators are presented. The synthesis of phosphonamidate MDP analogs was carried out by coupling of methyl(1R,S)-1-(N-benzyloxycarbonyl)aminoethyl phosphonate with Me D-isoglutamate hydrochloride, or (2S)-2-hydroxyglutaric acid di-Me ester, followed by coupling with 2-(2-phthalimidoethoxy)acetic acid, or 5-phthalimidopentanoic acid. The dipeptide part of the lead compd. was modified by introducing a phosphonamide isostere instead of the amide bond between L-alanine and D-glutamic acid (or D-isoglutamine), yielding new MDP analogs I (R1 = NH2, R2 = OMe, Y = CH2; R1 = R2 = OCH2Ph, Y = O). Furthermore, the amide bond between L-Ala and D-Glu was replaced by a phosphonate isostere, giving peptidyl phosphonate I (R1 = R2 = OMe, Y = O). The scope and limitations of the synthetic strategies employed are discussed. ..