Reference

Improving the stability of vitamin A in oil solutions

Improving the stability of vitamin A in oil solutions. Kozlov, E. I.; Ivanova, R. A. (Vses. Nauchno-Issled. Vitam. Inst., Moscow, USSR). Farmatsiya (Moscow), 26(2), 19-22 (Russian) 1977. CODEN: FRMTAL. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The stability of vitamin A acetate (I) [127-47-9] in oil solns. depended on the type of oil used, the initial concn. of I, and the identity and concn. of antioxidant added to the soln. The stability of I, as detd. by a 50% decrease in the initial I concn., was 5 times greater in corn oil then in sunflower oil, was greater in unrefined oil than in refined oil of the same species, and was always highest in freshly prepd. oils. I stability in soybean oils varied inversely with the initial vitamin concn. (the period of 50% degrdn. was 30, 9, 5, 4, and 3.5 days for initial I concns. of 1.5 .times. 104, 10 .times. 104, 20 .times. 104, 30 .times. 104, and 50 .times. 104 units/g. resp.). The antioxidative activity of certain compds. in 0.02% concns. for I in oils solns. decreased in the order diludine [1149-23-1], ascorbyl palmitate [137-66-6], butylated hydroxytoluene (BHT) [128-37-0], Pr gallate [121-79-9], BHT and butylated hydroxyanisole (BHA) [25013-16-5] (1:1), santoquin [91-53-2], and BHA.

Antioxidants and the prolongation of life

Antioxidants and the prolongation of life. Emanuel, N. M. (Inst. Chem. Phys., Moscow, USSR). Fiziol. Zh. (Kiev), 30(1), 1-8 (Russian) 1984. CODEN: FIZHDO. 15325-29-8 and 2364-75-2 are cas registry numbers of chemicals which are used as reagents here. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Mice of different strains were fed antioxidants mixed in their food. 2-Ethyl-6-methyl-3-hydroxypyridine (I) [2364-75-2] (150-200 mg/kg) and ethidine (II) [1149-23-1] (175 mg/kg) prolonged the av. life spans and markedly increased the maximal life spans, although genetic differences were obsd. I prevented the accumulation of defects in DNA secondary structure. Ambunol [2226-97-3] (20 mg/kg) and dimethyl-di-(p-phenylaminophenoxy)silane [15325-29-8] (50 mg/kg) were ineffective as life-extenders. .