Detail of "1149-24-2"

Reference

Drug metabolism in cell culture

Drug metabolism in cell culture. II. Studies on the metabolic route of DDC analogs. Racz, William J.; Hunter, Lynette; Wanless, Richard G. F.; McDonald, Miriam V.; Moffat, Joyce A. (Dep. Pharmacol., Queen's Univ., Kingston, Ont., Can.). Can. J. Physiol. Pharmacol., 55(3), 552-9 (English) 1977. CODEN: CJPPA3. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 3 To elucidate the major metabolic pathways of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC)(I) [632-93-9] analogues, the effect of inhibitors of oxidative and hydrolytic microsomal enzymes on the rate of metabolism of these compds. in chick embryo liver cell cultures has been examd. The metab. of 3,5-diethoxycarbonyl-2,4,6-trimethylpyridine (Ox-DDC) [1150-55-6] was inhibited threefold by piperonyl butoxide [51-03-6] and SKF-525A [62-68-0], but only onefold by bis(p-nitrophenyl)phosphate (BNPP) [645-15-8]. This indicates that this compd. is metabolized predominately by an oxidative route and hydrolysis is a minor pathway. The half-life of 3,5-diethoxycarbonyl-2,6-dimethylpyridine (4-desmethyl-Ox-DDC) [1149-24-2] was increased 20-fold by BNPP, but no change was obsd. with piperonyl butoxide, indicating that this compd. is metabolized exclusively by hydrolytic mechanisms. Since both piperonyl butoxide and BNPP produced similar changes in the half-life of I, it appears that this compd. is metabolized equally via oxidative and hydrolytic mechanisms. In contrast to the intact embryo, in cell culture, Ox-DDC is metabolized at a rate sufficiently slow so that induction of .delta.-aminolevulinic acid synthetase (EC 2.3.1.37) [9037-14-3] synthetase does occur.

Reaction of diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate with fullerene C60

Reaction of diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate with fullerene C60. Goldshleger, N. F.; Astakhova, A. S.; Lobach, A. S.; Boiko, G. N.; Denisov, N. N.; Nadtochenko, V. A.; Roshchupkina, O. S.; Shul'ga, Yu. M. (Inst. Chem. Physics Chernogolovka, Russian Academy Sciences, Chernogolovka 142432, Russia). Izvestiya Akademii Nauk, Seriya Khimicheskaya, (10), 2531-2534 (Russian) 1996 Institut Organicheskoi Khimii im. N. D. Zelinskogo Rossiiskoi Akademii Nauk. CODEN: IASKEA. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 25 Heating (100°, toluene) or photolysis (Nd3+:YAG laser, l = 532 nm, benzonitrile) of a mixt.In this experiment, several chemicals are used like 1149-24-2 and 1149-23-1 of di-Et 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (Hantzsch ester) (1) and fullerene C60 under anaerobic conditions results in the formation of fullerene hydrogenation products and di-Et 2,6-dimethylpyridine-3,5-dicarboxylate, the product of dehydrogenation of 1, identified by IR and mass spectrometry. The triplet state of C60 is quenched by 1. .