Reference

Preparation of aryloxyuronium salts as coupling agents for peptide preparation

Preparation of aryloxyuronium salts as coupling agents for peptide preparation. Von Baehr, Ruediger; Beyermann, Michael; Euthin, Elke; Pipkorn, Ruediger; Baehr, Ruediger Von (Humboldt-Universitaet zu Berlin, Germany). Ger. (East) DD 295376 A5 31 Oct 1991, 7 pp. (German Democratic Republic). CODEN: GEXXA8. CLASS: ICM: C07D401-14. ICS: C07D213-89; C07D211-22. APPLICATION: DD 90-342442 2 Jul 1990. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 34 Title compds. (I; X = pyrid-2-one oxide, pentafluorophenoxy; Y = Cl, BF4, PF6, etc.; Z = (CH2)n, CH2CH2OCH2CH2; n = 4-6), were prepd. Thus, 1,1,3,3-bis(pentamethylene)urea was treated with COCl2 or (COCl)2 to give the uronium chloride, which was treated with NaBF4 and then 2-pyridone to give title compd. II. II was used in soln. and solid-phase peptide coupling; e.g., Z-Val-Gly-OEt was prepd. in 91% yield.Except for chemicals metioned above, 1149-26-4 and 19794-17-3 are also used. .

Studies on activating methods of functional groups

Studies on activating methods of functional groups. Part IX. A convenient synthesis of peptide using oxalates. Takeda, Kazuyoshi; Sawada, Izumi; Suzuki, Akira; Ogura, Haruo (Sch. Pharm. Sci., Kitasato Univ., Tokyo 108, Japan). Tetrahedron Lett., 24(41), 4451-4 (English) 1983. CODEN: TELEAY. ISSN: 0040-4039. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) N-Protected amino acids were coupled with amino acid esters or amino acids by oxalates I (R = R1 = H, RR1 = benzo), II (R2 = H, Cl), and III in MeCN to give the corresponding dipeptides in good yields (64-100%) via active esters. I, II, and III were prepd.In this experiment, several chemicals are used like 56-41-7 and 1149-26-4 by treating ClCOCOCl with the appropriate N-hydroxy imides or 1-hydroxybenzotriazole derivs. .