Detail of "115-02-6"

MSDS Download
CAS Number:
115-02-6
Name:
L-Serine,O-(2-diazoacetyl)-
Molecular Structure:
Formula:
C5H7 N3 O4
Molecular Weight:
173.15
Synonyms:
L-Serine,diazoacetate (ester) (9CI); Serine, diazoacetate (ester), L- (6CI,8CI);Azaserin; Azaserine; CI 337; CN 15757; L-Azaserine; NSC 742;O-Diazoacetyl-L-serine; P 165
Density:
g/cm³
Boiling Point:
°Cat760mmHg
Flash Point:
°C
Hazard Symbols:
Risk Codes:
25-40
Safety:
Suspected carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Poison by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. Details

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Effects of coffee on the pancreas: Effects of coffee on the pancreas. Stalder, R.; Mueller, A. M. (Res. Dep., NESTEC Ltd., Vevey CH-1800, Switz.). Colloq. Sci. Int. Cafe, [C. R.], 11th, 113-20 (English) 1985. CODEN: CICRD8. DOCUMENT TYPE: Journal CA Section: 17 (Food and Feed Chemistry) Rats fed instant coffee (5%) added to the powd. diet prior to pelleting, before and after 6 weekly i.p. injections, followed by monthly injections for 1 yr, of azaserine [115-02-6] were examd. for the development of pancreatic tumors. Hypertrophy of the pancreas was obsd. after 4 wk of coffee ingestion both in animals receiving azaserine and in those not receiving azaserine. Coffee did not increase the mortality of rats in which pancreatic tumors had been induced by azaserine and tumor development was not accelerated by coffee.

Effect of chemical carcinogens on pancreatic DNA synthesis in vivo: Effect of chemical carcinogens on pancreatic DNA synthesis in vivo. Konishi, Yoichi; Denda, Ayumi; Takahashi, Seiichi; Sunagawa, Masayoshi; Kondo, Hiromu (Cancer Cent., Nara Med. Univ., Nara, Japan). Gann, 67(6), 781-6 (English) 1976. CODEN: GANNA2. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Pancreatic DNA synthesis following partial pancreatectomy of rats was inhibited by the pancreatic nonendocrine carcinogens N-bis(2-hydroxypropyl)nitrosamine [53609-64-6], N-methyl-N-nitrosourethane [615-53-2], azaserine [115-02-6], and 4-hydroxyaminoquinoline 1-oxide (I) [4637-56-3] by 57.9, 76.4, 71.7, and 82.There are some commonly used reagents with their cas registry numbers 13073-35-3 and 62-75-9 in this article.1%, resp. Pancreatic DNA synthesis was not inhibited by dimethylnitrosamine [62-75-9] or ethionine [13073-35-3], which are nonpancreatic carcinogens. The effect of streptozotocin [18883-66-4], a pancreatic endocrine carcinogen, on DNA synthesis was not clear. .