Detail of "115-38-8"

CAS Number:
115-38-8
Name:
2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-1-methyl-5-phenyl-
Superlist Name:
Mephobarbital
Molecular Structure:
Formula:
C₁₃H₁₄N₂O₃
Molecular Weight:
246.29
Synonyms:
Barbituricacid, 5-ethyl-1-methyl-5-phenyl- (8CI);(RS)-Mephobarbital;(RS)-Methylphenobarbital;1-Methyl-5-ethyl-5-phenylbarbituric acid;1-Methyl-5-phenyl-5-ethylbarbituric acid;1-Methylphenobarbital;5-Ethyl-5-phenyl-N-methylbartituric acid;5-Ethyl-N-Methyl-5-phenylbarbituric acid;5-Phenyl-5-ethyl-3-methylbarbituricacid;Enfenemal;Enphenemal;Isonal;Mebaral;Menta-Bal;Mephobarbitone;Mephytal;Methyl-calminal;Methylphenobarbitone;Metylfenemal;Metyna;Morbusan;N-Methyl-5-phenyl-5-ethylbarbital;N-Methylethylphenylbarbituric acid;N-Methylphenobarbital;Phemetone;Phemitone;
EINECS:
204-085-7
Density:
1.212 g/cm³
Melting Point:
176 °C
Boiling Point:
395.9 °C at 760 mmHg
Flash Point:
193.2 °C
Appearance:
white crystalline solid
Transport Information:
UN 3249

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Gas-liquid chromatographic determination of antiepileptic drugs in serum: Gas-liquid chromatographic determination of antiepileptic drugs in serum. Kumps, A.; Lowenthal, A.; Mardens, Y.; Coucheir, R. (Pharm. Inst., Free Univ. Brussels, Brussels, Belg.). Drug Interference Drug Meas. Clin. Chem.In this article, certain chemicals are used. Some of their cas registry numbers are 57-41-0 and 50-06-6 , Proc. Int. Colloq. Prospective Biol., 3rd, Meeting Date 1975, 131-5. Edited by: Siest, G.; Young, D. S. Karger: Basel, Switz. (English) 1976. CODEN: 34UHAM. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) A rapid, specific extn. procedure from blood serum is described for the detn. of phenobarbital (I) [50-06-6], mephobarbital [115-38-8], diphenylhydantoin [57-41-0], primidone [125-33-7], and ethosuximide [77-67-8]. The specificity and selectivity of the method are improved by the use of methanolic tetraethylammonium hydroxide as an alkylating reagent. .

Inhibition of amino acid transmitter release from rat brain slices by phenytoin and related anticonvulsants: Inhibition of amino acid transmitter release from rat brain slices by phenytoin and related anticonvulsants. Skerritt, John H.; Johnston, Graham A. R. (Dep. Pharmacol., Univ. Sydney, Sydney, Australia). Clin. Exp. Pharmacol. Physiol., 10(5), 527-33 (English) 1983. CODEN: CEXPB9. ISSN: 0305-1870. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The in vitro effects of the major nonbenzodiazepine anticonvulsants were studied upon K-stimulated release of radiolabeled GABA [56-12-2] and D-aspartate [1783-96-6] from slices of rat cerebral cortex. 61-56-3 and 77-41-8 which are cas registry numbers of substances are two of reagents here. At 100 mmol/L, some anticonvulsants effective in grand mal seizures (phenytoin [57-41-0], phenobarbitone [50-06-6], mephobarbitone [115-38-8], and beclamide [501-68-8]) selectively inhibited K-evoked release of the excitant amino acid D-aspartate, consistent with an anticonvulsant action. In contrast, several other anticonvulsants, namely ethosuximide [77-67-8], methsuximide [77-41-8], carbamazepine [298-46-4], sulthiame [61-56-3] and dipropylacetate [99-66-1] failed to alter K-evoked release of either amino acid. The ionic basis of phenytoin action on release was further studied; interactions with both neuronal Ca and Na ion channels appear necessary for the drug's inhibitory action. .