Reference

Complex effects of CNQX on CA1 interneurons of the developing rat hippocampus

Complex effects of CNQX on CA1 interneurons of the developing rat hippocampus. Maccaferri, G.; Dingledine, R. (Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA). Neuropharmacology, 43(4), 523-529 (English) 2002 Elsevier Science Ltd. CODEN: NEPHBW. ISSN: 0028-3908. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The authors have investigated the effect of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, 6-cyano-7-nitro-quinoxaline-2,3-dione (CNQX), on spontaneous GABAA receptor-mediated transmission in the hippocampal CA1 subfield. On av., simultaneous recordings from CA1 str. radiatum interneurons and pyramidal cells showed that CNQX application doubled the frequency of bicuculline sensitive spontaneous inhibitory postsynaptic currents (sIPSCs) without apparently changing their amplitude. However, despite the increase in sIPSC frequency, current-clamp recording showed that CNQX application was sufficient in most cases to depolarize interneurons to firing threshold. 115066-14-3 is also in the experiment. In contrast, CNQX application could not induce firing in pyramidal cells. In the presence of tetrado-toxin (TTX), CNQX increased interneuron membrane conductance, and depolarized interneurons from resting potentials. The axons of the studied interneurons ramify widely in the CA1 region and suggest that the cells of the authors' sample are mostly involved with control of dendritic excitability. The authors' results indicate that CNQX-induced increase of sIPSC frequency is not limited to excitatory cells, but also impacts GABAergic interneurons. However, despite the increase of sIPSC frequency, CNQX-induced depolarization is sufficient to selectively generate firing in interneurons and thus modify the network properties mediated by GABAA receptors in the hippocampus. .

3D-QSAR of a number of new non-NMDA receptor antagonists

3D-QSAR of a number of new non-NMDA receptor antagonists. Naerum, L.; Jensen, J. S. (CNS-Div., Novo-Nordisk, Soeborg DK-2860, Den.). Pharmacochem. Libr., 16(QSAR: Ration. Approaches Des. Bioact. Compd.), 489-92 (English) 1991. CODEN: PHLIDQ. ISSN: 0165-7208. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Two independent QSAR methods have been used in order to correlate the biol. activity and structure of a no. of new non-NMDA receptor antagonists. The compds. studied are derived from the non-NMDA receptor antagonist CNQX (I). 115066-14-3 which is the cas registry number of one of substances is just one of reagents here. One QSAR method is based on traditional mol. substituent parameters while the other is based on the relatively new CoMFA approach. Both methods yielded very good results. .