Detail of "1161-13-3"

CAS Number:
1161-13-3
Name:
N-Cbz-L-Phenylalanine
Molecular Structure:
Formula:
C₁₇H₁₇NO₄
Molecular Weight:
299.35
Synonyms:
(Benzyloxycarbonyl)phenylalanine;(2S)-3-phenyl-2-phenylmethoxycarbonylamino-propanoic acid;Alanine, N-carboxy-3-phenyl-, N-benzyl ester, L-;N-((Phenylmethoxy)carbonyl)-L-phenylalanine;3-phenyl-2-phenylmethoxycarbonylamino-propanoic acid;L-N-Carboxy-3-phenylalanine N-benzyl ester;Z-L-Phe-OH;Z-PHE-OH;CBZ-L-Phenylalanine;CBZ-L-Phe-OH;Cbz-Phe-OH;Z-L-Phenylalanine;N-Carbobenzyloxy-L-Phenylalanine;N-Z-L-Phenylalanine;N-Benzyloxycarbonyl-L-phenylalanine;
EINECS:
214-599-3
Density:
1.248 g/cm³
Melting Point:
85-88 °C
Boiling Point:
511.5 °C at 760mmHg
Flash Point:
263.1 °C
Appearance:
white amorphous powder
Hazard Symbols:
Xn
Risk Codes:
62-36/37/38-20/21/22
Safety:
22-24/25-36-26 Details

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Reference

Spasticity phenomena caused by N-substituted phenylalanine: Spasticity phenomena caused by N-substituted phenylalanine. Blum, B.; Segal, R.; Shtacher, G.; Shohat, B. (Sackler Sch. Med., Tel-Aviv Univ., Tel-Aviv-Jaffa, Israel). Pharmacol., Biochem. Behav., 8(1), 19-23 (English) 1978. CODEN: PBBHAU. ISSN: 0091-3057. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Symptoms which are pathognomonic of spasticity were induced in mice, rats, cats, and squirrel monkeys by i.v. or i.p. injections of N-carbobenzoxy-L-phenylalanine [1161-13-3] or N-carbobenzoxy-D-phenylalanine (I) [2448-45-5] or N-t-butoxycarbonyl-L-phenylalanine [13734-34-4] in doses of ~ 100 mg/kg. Such effects were not induced by the administration of other amino acids with similar substitutents, phenylalanine [63-91-2], or the other amino acids themselves. The spasticity-like symptoms characteristically appeared in the midst of elicited motor activity except in mice that showed them also at rest. The latency for the appearance of the symptoms was 4-7 min. These symptoms included asym. extensor spasms of the hindlimbs and flexor spasms in the forelimbs in mice, rats and cats; flexor spasms of the forelimbs and paresis of the hindlimbs in the squirrel monkeys. Hyperactive tendon tap reflexes were noted in all of these species as well as weak rightening reflexes, deficiency in antigravity reactions, and severe motor incoordination. Signs which are typical of spasticity obsd. in the monkey included the clasp knife sign, and in the cat, the lengthening reaction. In most cases, symptoms subsided within a week, but long-lasting incoordination was often obsd. In few animals, severe massive rigidity evolved after a few days which sometimes terminated fatally. L-Dopa [59-92-7] showed no antagonistic effect against I-induced spastic symptoms. In view of the specificity of the disturbances, a circumscribed brain pathol. may be responsible.

Synthesis of tert-butoxycarbonyl and benzyloxycarbonyl amino acid amides: Synthesis of tert-butoxycarbonyl and benzyloxycarbonyl amino acid amides. Rzeszotarska, B.; Makowski, M.; Kubica, Z. (Inst. Chem., Pedag. Univ., Opole 45-052, Pol.). Org.In this article, certain chemicals are used. Some of their cas registry numbers are 13734-41-3 and 1161-13-3 Prep. Proced. Int., 16(2), 136-9 (English) 1984. CODEN: OPPIAK. ISSN: 0030-4948. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) Title compds. R-X-NH2 (R = Me3CO2C, PhCH2O2C; X = Gly, Phe, Val) were prepd. in 83-98% yields by amidating R-X-OH with conc. aq. NH3 by ClCO2CH2CHMe2 in THF contg. N-methylmorpholine. .

Detail of "1161-13-3"

N-Cbz-L-Phenylalanine

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Reference