Reference

Manufacture of semisynthetic penicillin

Manufacture of semisynthetic penicillin. (Lisac S. A., Spain). Japan. Kokai JP 51048684 26 Apr 1976 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07D499-12. APPLICATION: JP 74-118781 17 Oct 1974. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 28 I (R1, R2 = H, halogen, lower alkoxy), effective in treating gram-pos. bacteria-induced diseases, esp. mastitis, are prepd. by acylation of 6-aminopenicillanic acid (II) [551-16-6] with MeC.tplbond.CCOCl [39753-54-3], followed by treating the acylated compd. with phenylnitrile oxides in the presence of N-ethylpiperidine. Thus, SOCl2 was mixed with DMF in toluene, and MeC.tplbond.CCO2H and II were subsequently added to the mixt. to give an intermediate, which was treated with phenylnitrile oxide (PhCNO) [873-67-6] in N-ethylpiperidine at 20-5.degree. for 20 hr, and MeCOCH2CHMe2, H2O, and H3PO4 were added to sep. N-ethylpiperidine as the phosphate. 39753-54-3 and 60575-36-2 which are cas registry numbers of substances are two of reagents here. The toluene phase was sepd., dried, and treated with Na 2-ethylhexanoate in BuOH to give Na [(3-phenyl-5-methyl-4-isoxazolyl)carbonyl]penicillin (I, R1 = R2 = H; Na salt) [1173-88-2], m. 188.degree.. .

Infrared spectroscopy of aqueous antibiotic solutions

Infrared spectroscopy of aqueous antibiotic solutions. Wong, James S.; Rein, Alan J.; Wilks, Donald; Wilks, Paul, Jr. (IBM Instrum., Inc., Danbury, CT 06810, USA). Appl. Spectrosc., 38(1), 32-5 (English) 1984. CODEN: APSPA4. ISSN: 0003-7028. DOCUMENT TYPE: Journal CA Section: 16 (Fermentation and Bioindustrial Chemistry) Section cross-reference(s): 64 The IR spectra of aq. antibiotic solns. were obtained by using a new Liq. Analyzer accessory in a Fourier-transform IR (FT-IR) spectrometer. Based on a cylindrical internal reflectance element, the accessory provides a sufficiently short (~0.015 mm) effective path length for IR spectroscopy of aq. solns. from 3200 to 800 cm-1. Spectra of aq. solns. of penicillin V K [132-98-9], Na oxacillin [1173-88-2], and Na methicillin [132-92-3] are shown. By measuring the absorbance of the b-lactam carbonyl band, FT-IR spectroscopy with the accessory is sensitivity to <0.1% by wt. of antibiotic both in aq. soln. 132-98-9 and 132-92-3 which are cas registry numbers of substances are two of reagents here. and in fermn. broth. The method may be useful for monitoring fermn. reactions and subsequent chem. modifications. .