Detail of "117399-94-7"

Reference

Endothelin regulation of mucus glycoprotein secretion from feline tracheal submucosal glands

Endothelin regulation of mucus glycoprotein secretion from feline tracheal submucosal glands. Shimura, S.; Ishihara, H.; Satoh, M.In this study， 7440-70-2 and 117399-94-7 are also used.; Masuda, T.; Nagaki, N.; Sasaki, H.; Takishima, T. (Sch. Med., Tohoku Univ., Sendai 980, Japan). Am. J. Physiol., 262(2. Pt. 1), L208-L213 (English) 1992. CODEN: AJPHAP. ISSN: 0002-9513. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The effects of endothelin on both the TCA-precipitable 3H-labeled glycoconjugate release and intracellular Ca2+ concn. ([Ca2+]i) measured by the usage of fura-2 in submucosal glands isolated from feline trachea were examd. Endothelin-1 increased glycoconjugate release from the isolated glands in a dose-dependent fashion, reaching a response of 161% of the control at 10-6 M. Atropine, propranolol, phentolamine, or indomethacin did not produce any alterations in the ET-1-evoked glycoconjugate secretion from the isolated glands. In contrast, in tracheal explants which contained epithelium, ET-1 decreased the glycoconjugate secretion in a dose-dependent fashion, reaching a response of 59% of the control at 10-6 M. In the presence of cultured epithelial cells, ET-1 also decreased glycoconjugate secretion from isolated glands. In isolated glands, ET-1 produced a sustained increase in the [Ca2+]i which was abolished by the removal of Ca2+ from the medium or by the presence of cultured epithelial cells. Pretreatment with indomethacin failed to alter the epithelial inhibitory action evoked by ET-1 in both the glycoconjugate secretion and the [Ca2+]i in isolated glands. ET-2 and ET-3 failed to alter the glycoconjugate secretion or [Ca2+]i. Thus, ET-1 induces mucus glycoprotein secretion via a Ca2+ influx and it possibly augments an epithelial action inhibitory to the mucus glycoprotein secretion from airway submucosal glands. .

Contractile response of human omental arteries to endothelin

Contractile response of human omental arteries to endothelin. Vila, J. M.; Martin de Aguilera, E.; Irurzun, A.; Aldasoro, M.; Flor, B.; Lluch, S. (Dep. Fisiol., Univ.There are some reagents with their cas registry numbers 7440-70-2 and 117399-94-7 are used in this study. Valencia, Valencia 46010, Spain). J. Pharm. Pharmacol., 44(2), 105-8 (English) 1992. CODEN: JPPMAB. ISSN: 0022-3573. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The effects of endothelin were studied in isolated arterial segments (0.8-1 mm in external diam.) of human omental arteries obtained during the course of abdominal operations (15 patients, 7 men and 8 women). Paired segments, one normal and the other de-endothelized, were mounted for isometric recording of tension in organ baths. Endothelin produced concn.-dependent contractions with an EC50 value of 5.4 ′ 10-9M. Removal of extracellular Ca or addn. of the Ca channel blocker nicardipine (10-6 M) diminished but did not abolish responses to endothelin. Thus, endothelin exerts powerful contractile effects on human isolated omental arteries which are independent of the presence of an intact endothelial cell layer, this contraction cannot be explained solely by voltage-dependent Ca channels. .