Detail of "1175-06-0"

Reference

Modulation of the interbilayer hydration pressure by the addition of dipoles at the hydrocarbon/water interface

Modulation of the interbilayer hydration pressure by the addition of dipoles at the hydrocarbon/water interface. Simon, Sidney A.; McIntosh, Thomas J.; Magid, Alan D.; Needham, David (Med. Cent., Duke Univ., Durham, NC 27710, USA). Biophys. J., 61(3), 786-99 (English) 1992. CODEN: BIOJAU. ISSN: 0006-3495.In this article, certain chemicals are used. Some of their cas registry numbers are 1175-06-0 and 57-88-5 DOCUMENT TYPE: Journal CA Section: 6 (General Biochemistry) The effects of the cholesterol analog 5a-cholestan-3b-ol-6-one (6-ketocholestanol) on bilayer structure, bilayer cohesive properties, and interbilayer repulsive pressures have been studied by a combination of x-ray diffraction, pipet aspiration, and dipole potential expts. It is found that 6-ketocholesterol, which has a similar structure to cholesterol except with a keto moiety at the 6-position of the B ring, has quite different effects than cholesterol on bilayer organization and cohesive properties. Unlike cholesterol, 6-ketocholestanol does not appreciably modify the thickness of liq.-cryst. egg phosphatidylcholine (EPC) bilayers, and causes a much smaller increase in bilayer compressibility modulus than does cholesterol. These data imply that 6-ketocholestanol has both its hydroxyl and keto moieties situated near the water-hydrocarbon interface thus making its orientation in the bilayer different from cholesterol's. The addn. of equimolar 6-ketocholestanol into EPC bilayers increases the magnitude, but not the decay length, of the exponentially decaying repulsive hydration pressure between adjacent bilayers. Incorporation of equimolar 6-ketocholestanol into EPC monolayers increases the dipole potential by ~300 mV. These data are consistent with previous observation that the magnitude of the hydration pressure is proportional to the square of the dipole potential. These results mean that 6-ketocholestanol, despite its location in the bilayer hydrocarbon region, ~10? from the phys. edge of the bilayer, modifies the organization of interlamellar water. It was assumed that the incorporation of 6-ketocholestanol into EPC bilayers increases the hydration pressure, at least in part, by increasing the elec. field strength in the polar head group region. .

Zearalenone - induced uncoupling in plant mitochondria is sensitive to 6-ketocholestanol

Zearalenone - induced uncoupling in plant mitochondria is sensitive to 6-ketocholestanol. Macri, F.; Vianello, A.; Braidot, E.; Petrussa, E.; Mokhova, E.N. ( Department of Biology and Agro-industrial Economics, University of Udine, Udine I-33100, Italy). Biochemistry and Molecular Biology International, 39(5), 1001-1006 (English) 1996 Academic. CODEN: BMBIES. ISSN: 1039-9712. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) In the present paper, the mechanism of zearalenone (F-2)-induced uncoupling in pea mitochondria was studied. The uncoupling by F-2 was partially reversed by 6-ketocholestanol (kCh) under conditions in which kCh completely reversed the carbonyl cyanide p-trifluoromethoxyphenylhydrazone-induced uncoupling and almost did not affect the palmitate-induced uncoupling. 35988-42-2 and 1175-06-0 which are cas registry numbers of substances are two of reagents here. Recoupling effects of carboxyatractylate, ADP and cyclosporin A were small and could not essentially decrease the kCh-insensitive part of F-2-induced uncoupling. It is suggested that a protein, mediating kCh-sensitive uncoupling, is involved in the F-2 effect in plant mitochondria. .