CAS No.1177-87-3,Dexamethasone-17-acetate Suppliers,MSDS download

Products Categories

Pharmaceutical (220)
Organic Chemicals (31)
Others (12)
Plant Extract (7)
Reagent (5)
Materials (3)
Dyestuff and Pigment (1)
Food Additives (1)

Basic Information

Molecular Structure:
CAS No.:	1177-87-3
Name:	Dexamethasone-17-acetate
Article Data:	21

Formula:	C₂₄H₃₁FO₆
Molecular Weight:	434.505
Synonyms:	Dex-Cortideltacetate;Dexa-Cortisyl;Fortecortin;Fortecortin (crystal suspension);Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11b,16a)-;Pregna-1,4-diene-3,20-dione,9-fluoro-11b,17,21-trihydroxy-16a-methyl-, 21-acetate (6CI,8CI);16a-Methyl-9a-fluoroprednisolone 21-acetate;Dalalone DP;Dalalone LA;Decadron LA;Decadronal;Dectancyl;Dexamethasone acetate;
EINECS:	214-646-8
Density:	1.3 g/cm³
Melting Point:	238-240 ºC(lit.)
Boiling Point:	579.4 ºC at 760 mmHg
Flash Point:	304.2 ºC
Solubility:	5.47 mg/L at 25 ºC in water
Appearance:	White or almost white crystalline powder
Hazard Symbols:	Xi
Risk Codes:	43
Safety:	36/37
PSA:	100.90000
LogP:	2.46650

Synthetic route

: 1524-94-3
21-acetoxy-9-fluoro-11β,17-dihydroxy-16α-methyl-pregn-4-ene-3,20-dione

: 1177-87-3
betamethasone

Conditions

Conditions	Yield
With selenium(IV) oxide

: 912-38-9, 2884-51-7, 14622-51-6, 98573-86-5
21-acetoxy-9,11β-epoxy-17-hydroxy-16α-methyl-9β-pregna-1,4-diene-3,20-dione

: 1177-87-3
betamethasone

Conditions

Conditions	Yield
With tetrahydrofuran; chloroform; hydrogen fluoride

: 2884-51-7
17α,21-dihydroxy-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate

: 1177-87-3
betamethasone

Conditions

Conditions	Yield
With hydrogen fluoride In N,N-dimethyl-formamide at -10℃; for 3h; Temperature;
With hydrogen fluoride In chloroform

: 34542-57-9
16β-methyl-17a,11β,21-trihydroxy-9-bromopregna-4-ene-3,20-dione-21-acetate

: 1177-87-3
betamethasone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium acetate; ethanol 2: THF; CHCl3; HF 3: SeO2 View Scheme

: 18769-18-1, 34542-58-0, 104111-24-2, 104527-32-4
21-acetoxy-9,11β-epoxy-17-hydroxy-16α-methyl-9β-pregn-4-ene-3,20-dione

: 1177-87-3
betamethasone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: THF; CHCl3; HF 2: SeO2 View Scheme

: 19784-87-3
17,21-dihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione

: 1177-87-3
betamethasone

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: mit Hilfe von Pestalotia foedans 4: sodium acetate; acetic acid 5: N-bromo-acetamide; dichloromethane; tert-butyl alcohol / Reagens 4: wss. Perchlorsaeure, Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton 6: CHCl3; THF; HF View Scheme

: 115606-30-9
21-acetoxy-17-hydroxy-16α-methyl-11α-(toluene-4-sulfonyloxy)-pregna-1,4-diene-3,20-dione

: 1177-87-3
betamethasone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium acetate; acetic acid 2: N-bromo-acetamide; dichloromethane; tert-butyl alcohol / Reagens 4: wss. Perchlorsaeure, Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton 3: CHCl3; THF; HF View Scheme

: 78761-59-8
11α,17,21-trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione

: 1177-87-3
betamethasone

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 3: sodium acetate; acetic acid 4: N-bromo-acetamide; dichloromethane; tert-butyl alcohol / Reagens 4: wss. Perchlorsaeure, Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton 5: CHCl3; THF; HF View Scheme

: 6242-16-6
21-acetoxy-11α,17-dihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione

: 1177-87-3
betamethasone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 2: sodium acetate; acetic acid 3: N-bromo-acetamide; dichloromethane; tert-butyl alcohol / Reagens 4: wss. Perchlorsaeure, Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton 4: CHCl3; THF; HF View Scheme

: 10106-41-9
17α,21-dihydroxy-16α-methyl-1,4,9(11)-pregnatriene-3,20-dione 21-acetate

: 1177-87-3
betamethasone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N-bromo-acetamide; dichloromethane; tert-butyl alcohol / Reagens 4: wss. Perchlorsaeure, Erwaermen des Reaktionsprodukts mit Kaliumacetat in Aceton 2: CHCl3; THF; HF View Scheme

Total:194 Page 1 of 6 1 2 3 4 5 6 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 1177-87-3

Chemistry

IUPAC Name: [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Molecular Weight: 434.497743 [g/mol]
Molecular Formula: C₂₄H₃₁FO₆
XLogP3: 2.8
H-Bond Donor: 2
H-Bond Acceptor: 7
EINECS: 214-646-8
Product Categories: Biochemistry; Hydroxyketosteroids; Steroids
refractive index: 87 ° (C=1, Dioxane)
storage temp.: 2-8 °C
Index of Refraction: 1.571
Molar Refractivity: 109.82 cm³
Molar Volume: 334 cm³
Surface Tension: 52.9 dyne/cm
Density: 1.3 g/cm³
Flash Point: 304.2 °C
Enthalpy of Vaporization: 99.54 kJ/mol
Boiling Point: 579.4 °C at 760 mmHg
Vapour Pressure: 7.75E-16 mmHg at 25 °C
Water Solubility: 5.47 mg/L at 25 °C
Melting Point: 238-240 °C(lit.)
Classification Code of Dexamethasone acetate (CAS NO.1177-87-3): Anti-Inflammatory Agents; Reproductive Effect

Uses

1. Dexamethasone acetate (CAS NO.1177-87-3) is used to treat many inflammatory and autoimmune conditions, such as rheumatoid arthritis. It is useful to counteract allergic anaphylactic shock, if given in high doses. Dexamethasone acetate is used in transvenous screw-in cardiac pacing leads to minimize the inflammatory response of the myocardium.
2. In oncology, it is given to cancer patients undergoing chemotherapy, to counteract certain side-effects of their antitumor treatment. Dexamethasone can augment the antiemetic effect of 5-HT3 receptor antagonists like ondansetron. Dexamethasone acetate is also used in certain hematological malignancies, especially in the treatment of multiple myeloma, in which dexamethasone is given alone or together with thalidomide (thal-dex) or lenalidomide, or a combination of Adriamycin (doxorubicin) and vincristine (VAD). In brain tumours (primary or metastatic), Dexamethasone acetate is used to counteract the development of edema, which could eventually compress other brain structures. It is also given in cord compression where a tumor is compressing the spinal cord.
3. Dexamethasone acetate is the treatment for the very rare disorder of glucocorticoid resistance. In adrenal insufficiency and Addison's disease, it is prescribed when the person doesn't respond well to prednisone or methylprednisolone.
4. Dexamethasone acetate is used in the treatment of high altitude cerebral edema as well as pulmonary edema. It is commonly carried on mountain climbing expeditions to help climbers deal with altitude sickness.
5. Dexamethasone acetate has been used as an off-label pre-natal treatment for the symptoms of congenital adrenal hyperplasia (CAH) in female fetuses. has also been used in the hope of enhancing sports performance. Dexamethasone acetate is also used in a diagnostic context, namely in its property to suppress the natural pituitary-adrenal axis.
6. Combined with marbofloxacin and clotrimazole, dDexamethasone acetate used to treat difficult ear infections, especially in dogs. It can also be combined with Trichlormethiazide to treat horses with swelling of distal limbs and general bruising.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Experimental teratogenic and reproductive effects. A steroid. When heated to decomposition it emits toxic fumes of F⁻.
Hazard Codes: Xi
Risk Statements: 43
R43:May cause sensitization by skin contact ;
Safety Statements: 36/37
S36/37:Wear suitable protective clothing and gloves ;
WGK Germany: 3
RTECS: TU4050000

Specification

Dexamethasone acetate (CAS NO.1177-87-3), its Synonyms are 16alpha-Methyl-9alpha-fluoroprednisolone 21-acetate ; 9-Fluoro-11-beta,17,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione acetate ; 9alpha-Fluoro-16alpha-methylprednisolone acetate ; Decadron-LA ; Decadronal ; Dectan ; Dex-Cortidelt acetate ; Dexamethasone 21-acetate ; Fortecortin (VAN) ; Panasone ; Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11beta,16alpha)- ; Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-, acetate Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-, 21-acetate (8CI) .