CAS No.118-00-3,Guanosine Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	118-00-3
Name:	Guanosine
Article Data:	143

Formula:	C₁₀H₁₃N₅O₅
Molecular Weight:	283.244
Synonyms:	Inosine, 2-amino-;2-amino-9-pentofuranosyl-9H-purin-6-ol;Ribofuranoside, guanine-9, .beta.-D-;Guanine, 9-.beta.-D-ribofuranosyl-;D-Guanosine;Guanosine(GR);2-Amino-1,9-dihydro-9-beta-D-ribofuranosyl-6H-purin-6-one;Guo;Guanine-9-beta-D-ribofuranoside;2H-Purin-2-one,6-amino-1,3-dihydro-;beta-D-Ribofuranoside, guanine-9;2(3H)-Imino-9-.beta.-D-ribofuranosyl-9H-purin-6(1H)-one;9-beta-D-Ribofuranosylguanine;9H-purin-6-ol, 2-amino-9-pentofuranosyl-;9-(beta-D-Ribofuranosyl)guanine;2-Amino-9-.beta.-D-ribofuranosyl-9-H-purine-6(1H)-one;
EINECS:	204-227-8
Density:	2.258 g/cm³
Melting Point:	250 °C (dec.)(lit.)
Boiling Point:	775.9°C at 760 mmHg
Flash Point:	423.1oC
Solubility:	0.75 g/L (25 °C) in water
Appearance:	crystalline
Hazard Symbols:	T,Xi
Risk Codes:	25
Safety:	45-24/25-23
Transport Information:	UN 2811 6.1/PG 3
PSA:	159.51000
LogP:	-2.10550

Synthetic route

: 2-N-(N,N-dibenzylformamidino)-9-(2,3-O-benzylidene-β-D-ribofuranosyl)-guanine

: 118-00-3
G

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal; palladium hydroxide - carbon In water; tert-butyl alcohol at 20℃; under 2068.59 Torr; for 20h; Hydrogenolysis;	99%

: 2',3'-O-benzylidene-2N-dimethylaminomethylene guanosine

: 118-00-3
G

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal; palladium hydroxide - carbon In water; tert-butyl alcohol at 20℃; under 2068.59 Torr; for 20h; Hydrogenolysis;	98%

: 100313-43-7
N-2-(ethoxycarbonyl)guanosine

: 118-00-3
G

Conditions

Conditions	Yield
With pyridine; ammonium hydroxide at 45℃; for 48h;	95%

: 9-(2',3'-di-O-acetyl-β-D-ribofuranosyl)-N2-isobutanoylguanine

: 118-00-3
G

Conditions

Conditions	Yield
With ammonia In methanol at 25 - 28℃; for 10h;	90%

: 6979-94-8
2',3',5'-tri-O-acetyl-guanosine

: 118-00-3
G

Conditions

Conditions	Yield
With methanol; water; triethylamine at 71℃; Microwave irradiation;	89%

: 41623-91-0
2-bromo-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)hypoxanthine

: 118-00-3
G

Conditions

Conditions	Yield
With ammonia In methanol at 120℃;	80%
With ammonium hydroxide at 150℃; for 3h;	48%

: Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(6-diphenylcarbamoyloxy-2-isobutyrylamino-purin-9-yl)-tetrahydro-furan-3-yl ester

: 118-00-3
G

Conditions

Conditions	Yield
With methanol; ammonia for 24h; Ambient temperature;	80%

: 112233-75-7
2-(acetylamino)-6-(diphenylcarbamoyloxy)-9-(β-D-tri-O-acetylribofuranosyl)-9H-purine

: 118-00-3
G

Conditions

Conditions	Yield
With ammonia In methanol; water at 60℃;	75%
With methanol; ammonia for 24h; Ambient temperature;	75%

: 58917-66-1
2',1''-anhydro-5-<(1''-benzamido-1''-hydroxymethylene)amino>-1-(β-D-ribofuranosyl)imidazole-4-carboxamide

A: 118-00-3
G

B: [1-(15)N]guanosine

C: 103654-70-2
<15NH2>guanosine

Conditions

Conditions	Yield
With (15N)-ammonium chloride In dimethyl sulfoxide at 100℃; for 240h; Yields of byproduct given;	A n/a B 75% C n/a
With (15N)-ammonium chloride In dimethyl sulfoxide at 100℃; for 240h; Yield given. Yields of byproduct given;

...Expand

: 26001-38-7
8-mercaptoguanosine

: 118-00-3
G

Conditions

Conditions	Yield
With potassium bromide In water at 20℃; pH=7; Reagent/catalyst; Inert atmosphere; Irradiation;	57.4%
Multi-step reaction with 3 steps 1: dihydrogen peroxide; acetic acid / 48 h / 65 °C 2: lithium hydroxide; water-d2 / Sonication 3: 24 h / 50 °C View Scheme

Raw Materials

146-91-8

52-90-4

118-00-3

Downstream Products

578-76-7

73-40-5

146-91-8

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

The Guanosine, with the CAS registry number 118-00-3 and EINECS registry number 204-227-8, has the IUPAC name of 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one. It belongs to the following product categories: Pharmaceutical Intermediates; Purine; API intermediates; Biochemistry; Nucleosides and their analogs; Nucleosides, Nucleotides & Related Reagents; Bases & Related Reagents. And the molecular formula of the chemical is C₁₀H₁₃N₅O₅.

The Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a -N9-glycosidic bond, and is required for an RNA splicing reaction in mRNA. What's more, it is always used in herpes treatment.

The physical properties of Guanosine are as followings: (1)# of Rule of 5 Violations: 2; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 1.284; (5)ACD/KOC (pH 7.4): 1.278; (6)#H bond acceptors: 10; (7)#H bond donors: 6; (8)#Freely Rotating Bonds: 5; (9)Polar Surface Area: 155.22 Å²; (10)Index of Refraction: 1.955; (11)Molar Refractivity: 60.811 cm³; (12)Molar Volume: 125.448 cm³; (13)Polarizability: 24.107×10^-24cm³; (14)Surface Tension: 123.824 dyne/cm; (15)Density: 2.258 g/cm³.

You should be cautious while dealing with this chemical. It is toxic if swallowed. Therefore, you had better take the following instructions: Avoid contact with skin and eyes; In case of accident or if you feel unwell, seek medical advice immediately (show label where possible); Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer).

You can still convert the following datas into molecular structure:
(1)SMILES: c1nc2c(=O)[nH]c(nc2n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N
(2)InChI: InChI=1/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
(3)InChIKey: NYHBQMYGNKIUIF-UUOKFMHZBU

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	500mg/kg (500mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	intravenous	180mg/kg (180mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03206,

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