Detail of "118-42-3"

Reference

The effects of chloroquine and other retinotoxic drugs on axonal transport of proteins in rabbit vagus nerve

The effects of chloroquine and other retinotoxic drugs on axonal transport of proteins in rabbit vagus nerve. McLean, W. G.; Sjoestrand, J. (Dep. Pharmacol., Liverpool Polytech., Liverpool, Engl.). Br. J. Pharmacol., 60(2), 302P-303P (English) 1977. CODEN: BJPCBM. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In ligated rabbit vagus nerve and nodose ganglia prepns., chloroquine [54-05-7], hydroxychloroquine [118-42-3] (10-3M), thioridazine [50-52-2], clioquinol [130-26-7], and chlorpromazine [50-53-3] (10-4M) decreased the accumulation of 3H-labeled proteins in the nerve proximal to the ligature; 10-3M ethambutol had no effect. Chloroquine was more effective than hydroxychloroquine in decreasing the accumulation of proteins. Both chlorpromazine and chloroquine (at 10-3M) decreased protein synthesis. Thus these drugs, excepting ethambutol, inhibited axonal transport of proteins in vitro; chloroquine diphosphate (100 mg/kg) did not affect axonal transport of proteins in rabbits in vivo.

Effects of antimalarial drugs on interleukin 1-induced cartilage proteoglycan degradation in vitro

Effects of antimalarial drugs on interleukin 1-induced cartilage proteoglycan degradation in vitro. Rainsford, K. D. (Dep. Pharmacol., Univ. Cambridge, Cambridge CB2 2QD, UK). J. Pharm. Pharmacol., 38(11), 829-33 (English) 1986.Several reagents with their cas registry numbers 80789-70-4 and 500-92-5 are used here. CODEN: JPPMAB. ISSN: 0022-3573. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Previous studies having shown that chloroquine [54-05-7] and hydroxychloroquine [118-42-3] could reduce interleukin 1 (IL-1)-induced cartilage degrdn. in-vitro, the effects of a range of antimalarial drugs on the cartilage proteoglycan degrading actions of porcine leukocyte a-interleukin 1 were examd. using the std. bovine nasal cartilage culture system. The anti-IL-1 effects in this system were specific to several aminoquinoline and aminoacridine analogs having a side chain with a tertiary amino group similar to that of chloroquine. Aminoquinoline compds. devoid of this side chain and the tertiary amino, as well as pyrimidines or biguanides with antimalarial activity were without effect. Mefloquine [53230-10-7], the most potent of the compds. active against porcine a-IL-1, was only equipotent with chloroquine and its hydroxy analog against human recombinant a-IL-1. This suggests that there may be subtle differences in the receptors for these drugs and interleukins in bovine cartilage. The results provide further evidence for the specificity and utility of antimalarial drugs in the treatment of chronic inflammatory conditions, esp. in relation to actions on IL-1. .