Reference

Direct effect of bile salts and phospholipids on the physical properties of mucus

Direct effect of bile salts and phospholipids on the physical properties of mucus. Martin, G. P.; Marriott, C.; Kellaway, I. W. (Dep. Pharm., Univ. Nottingham, Nottingham, Engl.). Gut, 19(2), 103-7 (English) 1978. CODEN: GUTTAK. ISSN: 0017-5749. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Na deoxycholate [302-95-4], Na taurodeoxycholate [1180-95-6], Na glycocholate [863-57-0], and lysophosphatidylcholine all affected the rheol. properties of mucus, decreasing both viscosity and elasticity. This indicated a structural breakdown of the mucus, and was consistent with the concept that a regurgitation of doudenal contents into the stomach may be involved in the etiol. of gastric ulcer. The synthetic surfactant Na dodecyl sulfate [151-21-3] produced similar decreases in the viscosity of mucus, but phosphatidylcholine was without effect.

A comparative study of the effect of bile salts on the absorption of quinalbarbitone sodium in goldfish

A comparative study of the effect of bile salts on the absorption of quinalbarbitone sodium in goldfish. Marriott, Christopher; Kellaway, Ian W.Several substances are used for example 361-09-1 and 309-43-3 which are their cas registry numbers. (Dep. Pharm., Univ. Nottingham, Nottingham, Engl.). J. Pharm. Pharmacol., 28(8), 620-4 (English) 1976. CODEN: JPPMAB. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Bile salts increased the absorption of quinalbarbitone Na [309-43-3] by goldfish with an order of potency of Na taurodeoxycholate [1180-95-6] > Na chenodeoxycholate [2646-38-0] .gtoreq. Na deoxycholate [302-95-4] > Na cholate [361-09-1]. The differences between the bile salts were not due to variations in soly. or partitioning of the drug within the membrane by the bile salts or to the relative hydrophobicity of each mol. The bile salts may affect the integrity of the goldfish membrane thereby rendering it more permeable to the drug. .