Detail of "1183-35-3"

Reference

Importance of the lactone ring for the action of therapeutic doses of ouabain in guinea-pig atria

Importance of the lactone ring for the action of therapeutic doses of ouabain in guinea-pig atria. Ghysel-Burton, Josiane; Godfraind, T. (Lab. Pharmacodyn. Gen. Pharmacol., Univ Cathol. Louvain, Brussels, Belg.). J. Physiol. (London), 266(1), 75P-76P (English) 1977. CODEN: JPHYA7. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Ouabain [630-60-4] and ouabagenin [508-52-1] (1-10nM) stimulated the Na pump in isolated guinea pig atria, whereas dihydroouabain [1183-35-3] inhibited it. Unsatn. of the lactone ring of ouabain is therefore required for its biphasic action on the Na pump.

Intestinal secretion of organic ions and drugs

Intestinal secretion of organic ions and drugs. Lauterbach, F. (Inst. Pharmacol. Toxicol., Ruhr Univ. Bochum, Bochum, Ger.). Excerpta Med. Int. Congr. Ser., 391(Intest. Permeation, Proc. Workshop Conf. Hoechst, 4th), 173-95 (English) 1977. CODEN: EXMDA4. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 13 In isolated intestine mucosa, digoxin (I) [20830-75-5] appeared to be secreted into the lumen by an active process. Dihydrodigoxin [5297-10-9] was secreted as well as I, and secretion was completely blocked in anerobic conditions. However, tissue uptake of I and ouabain [630-60-4] was greater than that of dihydrodigoxin and dihydroouabain [1183-35-3]. The efflux of glycosides from the intestine appeared to be a multiexponential process involving intracellular compartments. The intestinal secretion of the sulfonic acid, .beta.-naphthol orange [633-96-5] was also demonstrated. Other aspects of the intestinal secretion of org. ions and drugs are reviewed.