CAS No.1188-21-2,N-Acetyl-L-leucine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	1188-21-2
Name:	N-Acetyl-L-leucine
Article Data:	45

Formula:	C₈H₁₅NO₃
Molecular Weight:	173.212
Synonyms:	Leucine,N-acetyl-, L- (8CI);(S)-2-Acetamido-4-methylpentanoic acid;Acetyl-L-leucine;Acetylleucine;N-Acetyl-L-(-)-leucine;
EINECS:	214-706-3
Density:	1.069 g/cm³
Melting Point:	187-190 °C(lit.)
Boiling Point:	369.7 °C at 760mmHg
Flash Point:	177.4 °C
Solubility:	0.81 g/100 mL (20 °C) in water
Appearance:	white crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	24/25-36-26
PSA:	66.40000
LogP:	1.01270

Synthetic route

: 64896-30-6
(Z)-2-Acetylamino-4-methyl-pent-2-enoic acid

: 1188-21-2
N-Ac-Leu

Conditions

Conditions	Yield
With hydrogen; rhodium(I)-bis(1,5-cyclooctadiene) tetrafluoroborate; triethylamine; (2R,2'R)-bis(diphenylphosphino)-(1R,1'R)-dicyclopentane In tetrahydrofuran at 20℃; under 750.075 Torr; for 24h;	100%
With hydrogen; Rh(I)-(S)-chairphos In tetrahydrofuran Product distribution; Ambient temperature; other catalyst; other solvents; influence on products' optical yields;
With hydrogen; (S)-(-)-(6,6’-dimethoxybiphenyl-2,2’-diyl)bis(diphenylphosphine); [rhodium(I)(norborna-2,5-diene)2]SbF6 In dichloromethane at 20℃; under 1292.87 Torr; for 24h;
With chiral (1,1'-ferrocenediyl)bis(phospholo[3,4-d][1,3]dioxole); hydrogen; bis(1,5-cyclooctadiene)rhodium(I) hexafluorophosphate In tetrahydrofuran at 20℃; under 775.743 Torr; for 1h;

: 61-90-5
L-leucine

: 108-24-7
acetic anhydride

: 1188-21-2
N-Ac-Leu

Conditions

Conditions	Yield
In water for 0.0666667h; Irradiation;	98%
With sodium hydrogencarbonate In water at 0 - 20℃; for 5h;	89%
With triethylamine In water at 20℃;	35%

: 57289-25-5
methyl N-acetyl-leucinate

A: 1188-21-2
N-Ac-Leu

B: 35799-87-2
methyl (R)-2-(N-acetylamino)-4-methylpentanoate

Conditions

Conditions	Yield
With sodium hydroxide; phosphate buffer; pronase EC 3.4.24.4 In tetrahydrofuran Ambient temperature;	A 79% B 91%

: 6600-40-4
L-Norvaline

: 108-24-7
acetic anhydride

: 1188-21-2
N-Ac-Leu

Conditions

Conditions	Yield
at 0 - 20℃;	89%

: 244250-56-4
(S)-benzyl 2-acetamido-4-methylpentanoate

: 1188-21-2
N-Ac-Leu

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; for 3h;	81%
With palladium 10% on activated carbon; hydrogen In ethanol at 50℃; for 3h;	81%

: 463-51-4
Ketene

: 61-90-5
L-leucine

: 1188-21-2
N-Ac-Leu

Conditions

Conditions	Yield
With sodium hydroxide

: 99-15-0
N-acetylleucine

: 1188-21-2
N-Ac-Leu

Conditions

Conditions	Yield
With (-)-α-fenchylamine

: 57289-25-5
methyl N-acetyl-leucinate

: 1188-21-2
N-Ac-Leu

: 57289-25-5
methyl N-acetyl-leucinate

A: 1188-21-2
N-Ac-Leu

B: 19764-30-8
N-acetyl-D-leucine

Conditions

Conditions	Yield
for 118h; carbonate hydrolyase EC 4.2.2.1 (bovine carbonic anhydrase, BCA), pH 7.5; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 4071-36-7
ethyl N-acetyl-leucinate

A: 1188-21-2
N-Ac-Leu

B: 75552-78-2
N-acetyl-O-ethyl-D-leucine

Conditions

Conditions	Yield
In ethanol; water at 35℃; for 48h; Yield given;

Raw Materials

108-24-7

61-90-5

75-36-5

830-03-5

Downstream Products

61-90-5

99-15-0

1480-30-4

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Specification

1. Introduction of N-Acetyl-L-leucine

N-Acetyl-L-leucine, with the IUPAC Name: (2S)-2-acetamido-4-methylpentanoic acid, is one kind of powder.
And it belongs to the Product Categories which include Amino Acids Derivatives; Amino Acid Derivatives; Amino Acids; Leucine [Leu, L]; Amino Acids and Derivatives; Ac-Amino Acids; Amino Acids (N-Protected); Biochemistry; N-Acetyl-Amino acid series; Amino Acid Derivatives; Leucine; Peptide Synthesis. When comes to the application, it is one type of biochemical reagent.

2. Properties of N-Acetyl-L-leucine

N-Acetyl-L-leucine has the following property datas: (1)XLogP3: 0.5; (2)H-Bond Donor: 2; (3)H-Bond Acceptor: 3; (4)EINECS: 214-706-3; (5)Melting Point: 187-190 °C(lit.); (6)Surface Tension: 37.2 dyne/cm; (7)Water Solubility: 0.81 g/100 mL (20 °C); (8)Density: 1.069 g/cm3; (9)Flash Point: 177.4 °C; (10)Enthalpy of Vaporization: 67.7 kJ/mol; (11)Boiling Point: 369.7 °C at 760 mmHg; (12)Vapour Pressure: 1.77E-06 mmHg at 25°C. When comes to the usage, it could be used for treating vestibular-related imbalance and vertigo.

3. Safty information about N-Acetyl-L-leucine
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25-36-26
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
HazardClass: IRRITANT

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