Reference

Preparation of N-nitratopivaloyl-S-acylcysteines and related compounds as cardiovascular agents

Preparation of N-nitratopivaloyl-S-acylcysteines and related compounds as cardiovascular agents. Sandrock, Klaus; Noack, Eike; Fritschi, Edgar; Kanzler, Ralf; Feelisch, Martin (Schwarz Pharma A.-G., Germany). Eur. Pat. Appl. EP 451760 A1 16 Oct 1991, 11 pp. DESIGNATED STATES: R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE.Some commonly used reagents like 1188-21-2 and 139146-67-1 are used in this experiment. (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07C323-59. ICS: C07C327-34; A61K031-265. APPLICATION: EP 91-105540 8 Apr 1991. PRIORITY: DE 90-4011505 10 Apr 1990. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 1, 63 O2NOCH2CR1R2(CH2)mCONR3(CH2)nCR4R5(CH2)oCOR [R = OH, alkoxy, alkenyloxy, aminoalkoxy, (substituted) aralkoxy, aryloxy, amino, amino acid residue; R1 = H, (substituted) alkyl; R2, R3 = H, alkyl; R4 = R2, Ph, methoxyphenyl, phenylalkyl, hydroxyalkyl, acylaminoalkyl, mercaptoalkyl, etc.; R5 = acylthioalkyl; or RR4 = ester or amide bond; R3R4 = (substituted) (S-interrupted) alkylene, alkenylene; m, n, o = 0-10], were prepd. Thus, N-acetylglycine and N-nitratopivaolylcysteine Et ester were condensed in CH2Cl2 using DCC to give N-nitratopivaloyl-S-(N-acetylglycyl)cysteine Et ester (I). I at 1.7 mmol/kg i.v. in dogs reduced systolic arterial pressure by 23 mmHg and central venous pressure by 46 mm Hg. Tablets were prepd. contg. I. .

Radical transformation kinetics in irradiated acetyl-L-leucine single crystals at room temperature

Radical transformation kinetics in irradiated acetyl-L-leucine single crystals at room temperature. Almanov, G. A.; Bogdanchikov, G. A.; Usov, O. M. (Tbilisi State Univ., Tbilisi 380028, USSR). Radiat. Phys. Chem. 105480-52-2 and 1188-21-2 which are cas registry numbers are also used here., 29(1), 75-7 (English) 1987. CODEN: RPCHDM. ISSN: 0146-5724. DOCUMENT TYPE: Journal CA Section: 74 (Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes) The radical (CH3)2CCH2CH(NHCOCH3)CO2H transforms into (CH3)2CCHCH2C(NHCOCH3)CO2H at temps. of 293-315 K by ae first-order reaction. The kinetic parameters detg. this reaction are k0 = 9.2 ′ 109 s-1 and EG = 20.0 ± 0.6 kcal/mol. The substitution of D for H in a-C does not affect the kinetic parameters which proves the absence of isotopic effects. .