Reference

Enantioselective conjugate addition of diethylzinc to chalcone catalyzed by Ni(acac)2 and chiral b-amino alcohols

Enantioselective conjugate addition of diethylzinc to chalcone catalyzed by Ni(acac)2 and chiral b-amino alcohols. Wang, Heng-Shan; Da, Chao-Shan; Xin, Zhuo-Qun; Su, Wu; Xiao, Yi-Nan; Liu, Da-Xue; Wang, Rui (Department of Biochemistry & Molecular Biology, School of Life Sciences, Lanzhou University, Gansu 730000, Peop. Rep. China). Chinese Journal of Chemistry, 21(8), 1105-1107 (English) 2003 Science Press. CODEN: CJOCEV. ISSN: 1001-604X. DOCUMENT TYPE: Journal CA Section: 21 (General Organic Chemistry) Section cross-reference(s): 29 Enantioselective conjugate addn. of diethylzinc to chalcone was carried out in the presence of Ni(acac)2 complexed with five pyrrolidinylmethanols derived from L-proline. (S)-N-Benzyl-2-(1-hydroxy-1-methylethyl) pyrrolidine was found to be the best ligand in asym. conjugate addn. among the five ligands. The products were obtained with up to 70% ee. The configuration of the product was detd. jointly by the substituents on the carbon of the hydroxy group and the nitrogen atom. 118970-95-9 and 110529-22-1 are just another two chemicals used in this study. .

Enantioselective addition of diethylzinc to aldehydes catalyzed by optically active C2-symmetrical bis-b-amino alcohols

Xu, Qianyong; Zhu, Guangming; Pan, Xinfu; Chan, Albert S. C. ( Northwest Institute of Nuclear Technology, Xi'an 710024, Peop. Rep. China). Chirality, 14(9), 716-723 (English) 2002 Wiley-Liss, Inc. CODEN: CHRLEP. ISSN: 0899-0042. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) The syntheses of new optically active C2-sym. bis-b-amino alcs. There are some commonly used reagents like 118970-95-9 in this article. from (S)-2-(1-hydroxy-1,1-diphenylmethyl)pyrrolidine are described. Attention is focused on bridges, which link the two b-amino alc. units. These new chiral ligands have been successfully applied in the catalytic enantioselective addn. of diethylzinc to aldehydes to give sec-alcs. in good yields with up to 95% enantiomeric excess. .