Detail of "1191-41-9"

Reference

Oxidation ability of polyunsaturated fatty acids

Oxidation ability of polyunsaturated fatty acids.Some chemicals with cas registry numbers like 1808-26-0 and 111-62-6 are also used. Abdullabekova, R. M.; Babanova, N. K.; Patokina, E. V.; Tentsova, A. I.; Sarycheva, I. K. (IMMI im. Sechenova, Moscow, USSR). Farmatsiya (Moscow), 36(1), 29-30 (Russian) 1987. CODEN: FRMTAL. ISSN: 0367-3014. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 45 The stability of polyunsatd. fatty acids to oxidn. was studied by an accelerating aging method at 70°. The oxidn. rate increased with increasing unsatn. Among 4 fatty acid esters studied, i.e., Et arachidonate [1808-26-0], Et linolenate [1191-41-9], Et linoleate [544-35-4] and Et oleate [111-62-6], Et arachidonate showed the least stability having the highest oxidn. rate. .

Arachidonic acid, 5,8,11-eicosatrienoic acid and 5,8,11,14,17-eicosapentaenoic acid

Arachidonic acid, 5,8,11-eicosatrienoic acid and 5,8,11,14,17-eicosapentaenoic acid. Dietary manipulation of the levels of these acids in rat liver and platelet phospholipids and their incorporation into human platelet lipids.Some chemicals with cas registry numbers like 111-62-6 and 20590-32-3 are also used. Weiner, Teresa Wilhelm; Sprecher, Howard (Dep. Physiol. Chem., Ohio State Univ., Columbus, OH 43210, USA). Biochim. Biophys. Acta, 792(3), 293-303 (English) 1984. CODEN: BBACAQ. ISSN: 0006-3002. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) Rats were fed diets in which the sole source of fat was either Et oleate [111-62-6], Et linoleate [544-35-4], Et linolenate [1191-41-9], or an equal mixt. of Et linoleate and Et linolenate. The level of arachidonic acid (n6) [506-32-1] in all phospholipids was not markedly altered by feeding linoleate vs. that found in chow-fed controls. In oleate-fed rats, the 5,8,11-eicosatrienoic acid (n9) [20590-32-3]/n6) ratio varied from 0.5 in liver phosphatidylethanolamine (PE) to 4.1 in liver phosphatidylinositol (PI), while ratios of 1.0, 1.1, 0.7, and 1.3 were found resp. for platelet PE, phosphatidylserine (PC), phosphatidylcholine (PS), and PI. Platelet PE contained a component tentatively identified as n9, which is consistent with the finding that this lipid contained significant amts. of n6 and n3 when rats received resp. linoleate or linolenate. Rats fed linolenate have a tight coupling between the regulation of unsatd. fatty acid biosynthesis and the selective acylation of 5,8,11,14,17-eicosapentaenoic acid (n3) [10417-94-4] into all lipids. The n3/n6 ratio, however, varied between lipids. In liver PE, PC, PS, and PI it was resp. 4.3, 4.9, 3.8, and 0.4, while in the analogous platelet lipids it was 3.0, 4.0, 0.9, and 0.6. Feeding linolenate did not markedly elevate the levels of n3 or n3 in platelet PI, but the combined amts. of n3 and n3 in liver PI were 21.2%, vs. 2.9% in chow-fed controls. When the diet contained linoleate and linolenate, there was selective conversion of n6 to n6 and its acylation into lipids vs. analogous metab. of n3 to n3 and its subsequent incorporation. Again, the n3/n6 ratio was lowest for platelet PI, and PS and liver PI. Washed human platelets readily incorporated n9, n6, and n3 into phospholipids. With each substrate, PI had the highest specific activity; this effect was most pronounced with n9. These incorporation studies are consistent with the feeding studies which show that oleate is converted to n9 and incorporated into PI more readily than the analogous metab. of n3 to n3 and its acylation into PI, which is an important source of unsatd. fatty acids for prostaglandin biosynthesis. .