Products Categories
| CAS No.: | 1193-21-1 |
|---|---|
| Name: | 4,6-Dichloropyrimidine |
| Article Data: | 40 |
| Molecular Structure: | |
|
|
|
| Formula: | C4H2Cl2N2 |
| Molecular Weight: | 148.979 |
| Synonyms: | 4,6-Dichloro Pyrimidine;Pyrimidine, 4,6-dichloro-; |
| EINECS: | 214-770-2 |
| Density: | 1.493 g/cm3 |
| Melting Point: | 65-67 °C(lit.) |
| Boiling Point: | 176 °C at 760 mmHg |
| Flash Point: | 105.1 °C |
| Appearance: | Yellow Solid |
| Hazard Symbols: |
 C
|
| Risk Codes: | 34-20/21/22-36/37 |
| Safety: | 26-36/37/39-45-27 |
| Transport Information: | UN 3263 8/PG 2 |
| PSA: | 25.78000 |
| LogP: | 1.78340 |
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| Conditions | Yield |
|---|---|
| With trichlorophosphate | 100% |
| With trichlorophosphate | 98% |
| Conditions | Yield |
|---|---|
| With triethylamine; trichlorophosphate at 40 - 105℃; for 2h; | 99.1% |
| With chlorine; magnesium chloride; phosphorus trichloride In trichlorophosphate at 66℃; under 750.075 Torr; for 3.5h; Reagent/catalyst; Temperature; Pressure; Solvent; | 99.83% |
| With bis(trichloromethyl) carbonate; sulfuric acid In N,N-dimethyl-formamide; 1,2-dichloro-benzene at 80℃; for 4.2h; Temperature; Solvent; Industrial scale; | 97% |
| Conditions | Yield |
|---|---|
| Stage #1: 4,6-diaminopyrimidine With hydrogenchloride; sodium nitrite In water at -5℃; for 2h; Stage #2: With hydrogenchloride; copper(l) chloride In water at 45℃; for 2h; | 86.4% |
| Conditions | Yield |
|---|---|
| With 2,3-Dimethylaniline In dichloromethane; water | 80% |
| With N-ethyl-N,N-diisopropylamine In water; acetonitrile |
- 89283-48-7
4-chloro-6-methylsulfanylpyrimidine
- 1193-21-1
4,6-dichloropyrimidine
| Conditions | Yield |
|---|---|
| With sulfuryl dichloride In dichloromethane; acetonitrile at 0℃; for 0.5h; | 76% |
- 75-44-5
phosgene
- 77287-34-4, 77287-35-5, 60100-09-6
formamide
- 75-05-8
acetonitrile
- 1193-21-1
4,6-dichloropyrimidine
| Conditions | Yield |
|---|---|
| at 20 - 140℃; under 982.607 - 20686.5 Torr; for 3h; the Parr Reactor (17328-33); | 62.21% |
| at 105℃; under 5999.08 - 8378.02 Torr; for 3h; | |
| With hydrogenchloride In chlorobenzene at 105℃; under 11739.6 Torr; for 23.5h; |
- 25286-58-2
1H-pyrimidine-4,6-dione
- 1193-21-1
4,6-dichloropyrimidine
| Conditions | Yield |
|---|---|
| With pyridine; trichlorophosphate | |
| With N,N-dimethyl-aniline; trichlorophosphate |
| Conditions | Yield |
|---|---|
| In tetrachloromethane at 34.9℃; Equilibrium constant; |
- 60-35-5
acetamide
- 75-44-5
phosgene
- 77287-34-4, 77287-35-5, 60100-09-6
formamide
- 1193-21-1
4,6-dichloropyrimidine
| Conditions | Yield |
|---|---|
| In chlorobenzene at 75 - 105℃; under 4913.04 - 17583.5 Torr; for 1.66667 - 23.1667h; |
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Chemistry
IUPAC Name: 4,6-Dichloropyrimidine
Synonyms of 4,6-Dichloropyrimidine (CAS NO.1193-21-1): Pyrimidine, 4,6-dichloro-
CAS NO: 1193-21-1
Molecular Formula: C4H2Cl2N2
Molecular Weight: 148.98
Molecular Structure: 
EINECS: 214-770-2
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 25.78 Å2
Index of Refraction: 1.559
Molar Refractivity: 32.22 cm3
Molar Volume: 99.7 cm3
Surface Tension: 51.5 dyne/cm
Density: 1.493 g/cm3
Flash Point: 105.1 °C
Enthalpy of Vaporization: 39.54 kJ/mol
Boiling Point: 176 °C at 760 mmHg
Vapour Pressure: 1.5 mmHg at 25°C
Melting Point: 65-67 °C(lit.)
Appearance:Yellow Solid
Product Categories of 4,6-Dichloropyrimidine (CAS NO.1193-21-1): PYRIMIDINE;FINE Chemical & INTERMEDIATES;Halides;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;Pyrazines, Pyrimidines & Pyridazines;Nucleotides and Nucleosides;Pyrimidines;Bases & Related Reagents;Nucleotides;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;PyrimidinesHeterocyclic Building Blocks
Uses
4,6-Dichloropyrimidine (CAS NO.1193-21-1) is used as intermediate in the synthesis of pharmaceutical.
Safety Profile
Safety Information about 4,6-Dichloropyrimidine (CAS NO.1193-21-1):
Hazard Codes : 
C
The Risk Statements: 34-20/21/22-36/37
34: Causes burns
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37: Irritating to eyes and respiratory system
The Safety Statements: 26-36/37/39-45-27
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
27: Take off immediately all contaminated clothing
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
RIDADR:UN 3263 8/PG 2
F:19
WGK Germany:3
Hazard Note : Corrosive
HazardClass :8
Specification
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use foam, dry chemical, or carbon dioxide.
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.
Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area.