Reference

Studies on azoles and azines

Studies on azoles and azines. CI. Reaction of 4,6-dihydroxypyrimidine and barbituric acid with 4,6-dihydroxypyrimidine-5-carboxaldehyde. Moskvin, A. V.; Petrova, N. M.; Ivin, B. A. (St. Peterburg. Gos. Khim.-Farm. Akad., St. Petersburg, Russia). 187036-57-3 and 1193-24-4 are also in the experiment. Zhurnal Obshchei Khimii, 66(10), 1748-1751 (Russian) 1996 Nauka. CODEN: ZOKHA4. ISSN: 0044-460X. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Barbituric acid reacted with 4,6-dihydroxypyrimidine-5-carboxaldehyde in water at 20-60° to give pyrimidinylmethylene deriv. I; in HOAc at 120° aminomethylene deriv. II was obtained. Reaction of 4,6-dihydroxypyrimidine with 4,6-dihydroxypyrimidine-5-carboxaldehyde gave pyranopyrimidinecarboxamides III (R = H, CHO). .

Preparation of pure 4,6-dichloropyrimidine

Preparation of pure 4,6-dichloropyrimidine. Huber, Wolfgang; Schwarz, Franz-Thomas; Heu, Ferdinand (Chemie Linz (Deutschland) Gmbh I.L., Germany). Ger. Offen. DE 19524283 A1 9 Jan 1997, 3 pp.Some commonly used reagents like 1193-24-4 and 1193-21-1 are used in this experiment. (German). (Germany). CODEN: GWXXBX. CLASS: ICM: C07D239-30. ICA: C07D239-54; B01J031-02. APPLICATION: DE 1995-19524283 4 Jul 1995. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) 4,6-Dichloropyrimidine (I) was prepd. by treatment of 4,6-dihydroxypyrimidine (II) with excess POCl3 in the presence of a trialkylamine as acid acceptor and catalyst. Thus, II and POCl3 were treated with Et3N over 120 min. and the mixt. was then heated 30 min. at 85° to give 89.1% I. .