Reference

Synthesis of (S)-3-aminoquinuclidine dihydrochloride

All Rights Reserved. Synthesis of (S)-3-aminoquinuclidine dihydrochloride. Liu, Yuhai; Wang, Decai (Pharmaceutical + Life Science College, Nanjing University of Technology, Nanjing 210009, Peop. Rep. China). Huagong Shikan, 19(2), 12-13 (Chinese) 2005 Huagong Shikan Zazhishe. CODEN: HUSHFT. ISSN: 1002-154X. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) (S)-3-Aminoquinuclidine dihydrochloride was synthesized from 3-quinuclidinone HCl and (R)-1-phenethylamine by three steps: ammoniation, redn. with NaBH4, and hydrogenation by 10% Pd/C instead of Pearlman's catalyst. 128311-06-8 and 1193-65-3 are also in the experiment. Hydrogenation/deprotection was carried out on (3S)-N-[(1R)-1-phenylethyl]-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride. The total yield was 35%. .

(Z)-2-(1H-Indol-3-ylmethylene)-1-azabicyclo[2

Some chemicals with cas registry numbers like 1193-65-3 are also used. (Z)-2-(1H-Indol-3-ylmethylene)-1-azabicyclo[2.2.2]octan-3-one.In this article, certain chemicals are used. One of their cas registry numbers is 1193-65-3 Sonar, Vijayakumar N.; Parkin, Sean; Crooks, Peter A. (College of Pharmacy, Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536, USA). Acta Crystallographica, Section C: Crystal Structure Communications, C60(1), o6-o8 (English) 2004 Blackwell Publishing Ltd. CODEN: ACSCEE. ISSN: 0108-2701. DOCUMENT TYPE: Journal CA Section: 75 (Crystallography and Liquid Crystals) Section cross-reference(s): 27 Crystals of the title compd. are monoclinic, space group Cc, with a 6.1800(12), b 44.160(9), c 9.774(2) ?, b 108.26(3)°; Z = 4 (2 mols./Z), dc = 1.323; R = 0.048, Rw(F2) = 0.080 for 2906 reflections. The compd. contains a double bond connecting an azabicyclic ring system to an indol-3-ylmethylene group. The geometries of the two crystallog. independent mols. are nearly identical. The crystal packing of the compd. involves two types of intermol. H bonds. ..