Reference

Reversal of neuromuscular blockade and simultaneous increase in plasma rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969

Reversal of neuromuscular blockade and simultaneous increase in plasma rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969. Epemolu, Ola; Bom, Anton; Hope, Frank; Mason, Rona (Department of Pharmacology, Organon Research, UK). Anesthesiology, 99(3), 632-637 (English) 2003 Lippincott Williams & Wilkins. CODEN: ANESAV. ISSN: 0003-3022. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The purpose of this study was to det. the changes in the plasma concn. of rocuronium and the reversal of its neuromuscular blockade after the i.v. infusion of Org 25969, the novel neuromuscular block-reversal agent, in anesthetized guinea pigs. Rocuronium was infused for 1 h at a rate of 12-19 nmol×kg-1×min-1 to produce a steady-state 90% neuromuscular block. After 30 min, a concomitant infusion of either the reversal agent Org 25969 at a rate of 50 nmol×kg-1×min-1 or an infusion of an equiv. vol. of saline was started. The time course of plasma concns. of rocuronium was detd. by use of liq. chromatog.-mass spectrometry/mass spectrometry. RESULTS: In both treatment groups, a steady-state plasma concn. of rocuronium was obtained after 30 min. In the saline-treated group, the plasma concn. of rocuronium and depth of block remained const. In the Org 25969 group, neuromuscular block was reversed while the rocuronium infusion was ongoing. Simultaneously, an increase in the total plasma concn. of rocuronium (free and complexed) was obsd., even though the infusion rate of rocuronium was not changed. 343306-79-6 and 119302-91-9 which are cas registry numbers of substances are two of reagents here. Compared with the saline-treated group, a small increase in the postmortem bladder concn. of rocuronium was detected. The authors propose that the capture of rocuronium by Org 25969 causes the rapid reversal of neuromuscular block. The reversal can be explained by the rapid transfer of free rocuronium from the effect compartment (neuromuscular junction) to the central compartment, in which it is bound to Org 25969. This explains the increase in total plasma concn. of rocuronium (free and bound to Org 25969). .

The role of magnesium as an adjuvant during general anaesthesia

All Rights Reserved. The role of magnesium as an adjuvant during general anaesthesia.In this study， 7487-88-9 and 119302-91-9 are also used. Gupta, K.; Vohra, V.; Sood, J. (Department of Anaesthesiology, Pain and Perioperative Medicine, Sir Ganga Ram Hospital, New Delhi 110060, India). Anaesthesia, 61(11), 1058-1063 (English) 2006 Blackwell Publishing Ltd. CODEN: ANASAB. ISSN: 0003-2409. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Magnesium sulfate is used extensively in the treatment of eclampsia, and is also used to treat refractory arrhythmias, asthma, myocardial ischemia and acute respiratory failure. We studied the interaction between magnesium sulfate and the anesthetic agents propofol, rocuronium bromide and fentanyl citrate. This randomized, double blind study was conducted in 50 patients. The magnesium group A (n = 25) received 30 mg.kg-1 magnesium sulfate before induction of anesthesia and 10 mg.kg-1 continuously intra-operatively until the end of surgery. Group B (n = 25) received the same vol. of isotonic saline. Propofol, rocuronium and fentanyl infusions were started and the patients lungs' were ventilated with 33% oxygen in nitrous oxide. Anesthetic depth was maintained at a bispectral index value of between 40 and 60. Muscle relaxation was maintained at a train-of-four count of 1 throughout surgery using neuromuscular monitoring. The fentanyl infusion was titrated to haemodynamic variables: heart rate and blood pressure. We concluded that magnesium sulfate has anesthetic, analgesic and muscle relaxation effects and significantly reduces the drug requirements of propofol, rocuronium and fentanyl during anesthesia. .