Reference

The luminescence properties of some antiinflammatory and antipyretic drugs

The luminescence properties of some antiinflammatory and antipyretic drugs. Miller, J. N.; Phillipps, D. L.; Burns, D. Thorburn; Bridges, J. W. (Dep. Biochem., Loughborough Univ., Loughborough, Engl.). Talanta, 25(1), 46-9 (English) 1978. CODEN: TLNTA2. ISSN: 0039-9140. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) The fluorescence and phosphorescence of 20 title drugs, e.g. indomethacin [53-86-1] and ibuprofen, were examd. to establish suitable conditions for their detn. Six were insufficiently luminescent but the remainder could be detd. at trace levels by luminescence spectrometry. Optimal conditions were established. E.g., in neutral or alk. EtOH p-H2NC6H4CH2CO2H [1197-55-3] showed an intense phosphorescence which could be used to det. the drug at concns. ~ng/mL, but in acid media the phosphorescence was weaker and the detection limit was ~10 mg/mL.

Structure-activity relations in a series of analogs of e-aminocaproic acid

Structure-activity relations in a series of analogs of e-aminocaproic acid. Shibut, V. P.; Zabelin, N. N.; Golubovich, V. P.; Akhrem, A. A. (Inst. Bioorg. Khim., Minsk, USSR). Vestsi Akad. Navuk BSSR, Ser. Khim. Navuk, (2), 69-74 (Russian) 1986. CODEN: VBSKAK. ISSN: 0002-3590. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 22 By means of empirical energy calcns. 60-32-2 which is the cas registry number of some chemical is mentioned., all low-energy conformations of e-aminocaproic acid [60-32-2] and its analogs g-aminobutyric acid [56-12-2], d-aminovaleric acid [660-88-8], w-aminoenanthic acid [929-17-9], 4-aminobenzoic acid [150-13-0], 4-aminomethylbenzoic acid [56-91-7], 4-aminoethylbenzoic acid [1199-68-4], 4-aminophenylacetic acid [1197-55-3], and 4-aminomethylphenylacetic acid [1200-05-1] were detd. Comparison of these detns. with what is known about the antifibrinolytic activities of these compds. makes possible some predictions concerning the biol. active conformation of e-aminocaproic acid when it complexes with fibrinolytic enzymes. The distance between the NH2 and CO2H groups is crit., but the immediate environment of the NH2 group is also very important. .