CAS No.119914-60-2,Grepafloxacin Suppliers

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Basic Information

Molecular Structure:
CAS No.:	119914-60-2
Name:	Grepafloxacin
Article Data:	4

Formula:	C₁₉H₂₂FN₃O₃
Molecular Weight:	359.4
Synonyms:	1-Cyclopropyl-6-fluoro-7-(3-methyl-1-piperazinyl)-5-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylicacid;Grepafloxacin;Tomefloxacin;dl-Grepafloxacin;
EINECS:	631-454-3
Density:	1.366 g/cm³
Melting Point:	189-192 ºC
Boiling Point:	610 °C at 760mmHg
Flash Point:	322.7 °C
PSA:	74.57000
LogP:	2.67400

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Specification

The IUPAC name of Grepafloxacin is 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid . With the CAS registry number 119914-60-2, it is also named as 1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-
piperazinyl)-4-oxo-3-quinolinecarboxylic acid ; CCRIS 7284 ; (+-)-1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid ; 3-Quinolinecarboxylic acid, 1,4-dihydro-1-cyclopropyl-6-fluoro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo- .

This product is white powder with small solubility in water, its hydrochloride is soluble in water. Grepafloxacin is a quinolone antibiotic which is used to treat pneumonia, bronchitis, uncomplicated gonorrhea, and Chlamydia infections. Grepafloxacin as a drug has an unpleasant taste and can cause sun sensitivity. Although it has reported it has caused skin rashes, nausea, and diarrhea, it is generally well tolerated. This drug should be carefully used by pregnant women and lactating mothers.

Grepafloxacin can interfere with bacterial DNA, and thus bacterial ability to reproduce. It is active against gram positive bacteria including penicillin resistant Strep pneumoniae. Grepafloxacin was manufactured by Otsuka Pharmaceutical Co. Ltd (Tokushima, Japan).

The other characteristics of this product can be summarized as: (1)ACD/BCF (pH 5.5): 1 ; (2)ACD/BCF (pH 7.4): 1 ; (3)ACD/KOC (pH 5.5): 1 ; (4)ACD/KOC (pH 7.4): 1.63 ; (5)#H bond acceptors: 6 ; (6)#H bond donors: 2 ; (7)#Freely Rotating Bonds: 3 ; (8)Index of Refraction: 1.623 ; (9)Molar Refractivity: 92.78 cm³ ; (10)Molar Volume: 263 cm³ ; (11) Polarizability: 36.78×10^-24 cm³ ; (12)Surface Tension: 58 dyne/cm ; (13)Enthalpy of Vaporization: 95.26 kJ/mol ; (14)Vapour Pressure: 9.83E-16 mmHg at 25°C.

People can use the following data to convert to the molecule structure. SMILES: O=C(O)\C2=C\N(c1cc(c(F)c(c1C2=O)C)N3CC(NCC3)C)C4CC4; InChI: InChI=1/C19H22FN3O3/c1-10-8-22(6-5-21-10)15-7-14-16(11(2)17(15)20)18(24)13(19(25)26)9-23(14)12-3-4-12/h7,9-10,12,21H,3-6,8H2,1-2H3,(H,25,26).